RT Journal Article
T1 Parabrachial Interleukin-6 reduces body weight and food intake and increases thermogenesis to regulate energy metabolism
A1 Mishra, Devesh
A1 Richard, Jennifer E.
A1 Maric, Ivana
A1 Porteiro Couto, Begoña
A1 Häring, Martin
A1 Kooijman, Sander
A1 Musovic, Saliha
A1 Eerola, Kim
A1 López Ferreras, Lorena
A1 Peris, Eduard
A1 Grycel, Katarzyna
A1 Shevchouk, Olesya T.
A1 Micallef, Peter
A1 Olofsson, Charlotta S.
A1 Wernstedt Asterholm, Ingrid
A1 Grill, Harvey J.
A1 Nogueiras Pozo, Rubén
A1 Skibicka, Karolina P.
K1 Lateral PBN
K1 Hindbrain
K1 Energy balance
K1 Cold exposure
K1 Obesity
K1 Thyroid
K1 Brown adipose tissue
K1 Diet-induced obesity
K1 Sex differences
K1 PVN
AB Chronic low-grade inflammation and increasedserum levels of the cytokine IL-6 accompany obesity.For brain-produced IL-6, the mechanisms by which itcontrols energy balance and its role in obesityremain unclear. Here, we show that brain-producedIL-6 is decreased in obese mice and rats in a neuroanatomically and sex-specific manner. Reduced IL-6mRNA localized to lateral parabrachial nucleus(lPBN) astrocytes, microglia, and neurons, includingparaventricular hypothalamus-innervating lPBN neurons. IL-6 microinjection into lPBN reduced foodintake and increased brown adipose tissue (BAT)thermogenesis in male lean and obese rats byincreasing thyroid and sympathetic outflow to BAT.Parabrachial IL-6 interacted with leptin to reducefeeding. siRNA-mediated reduction of lPBN IL-6leads to increased weight gain and adiposity,reduced BAT thermogenesis, and increased foodintake. Ambient cold exposure partly normalizesthe obesity-induced suppression of lPBN IL-6. Theseresults indicate that lPBN-produced IL-6 regulatesfeeding and metabolism and pinpoints (patho)physiological contexts interacting with lPBN IL-6
PB Cell Press
SN 2211-1247
YR 2019
FD 2019
LK http://hdl.handle.net/10347/21799
UL http://hdl.handle.net/10347/21799
LA eng
NO Mishra et al. (2019). Parabrachial Interleukin-6 Reduces Body Weight and Food Intake and Increases Thermogenesis to Regulate Energy Metabolism.  Cell Reports 26, 3011–3026. doi: 10.1016/j.celrep.2019.02.044
NO This research was funded by the Swedish Research Council ( 2014-2945 to K.P.S.; 2017-00792 to I.W.A.; and 2013-7107 to Patrik Rorsman), the Novo Nordisk Foundation Excellence project grant (to K.P.S. and I.W.A.), the Ragnar Söderberg Foundation (to K.P.S.), Harald Jeanssons Stiftelse and Greta Jeanssons Stiftelse (to K.P.S.), Magnus Bergvalls Stiftelse (to K.P.S.), the Wallenberg Foundation and the Center for Molecular and Translational Medicine (to K.P.S.), postdoctoral stipendium from The Swedish Brain Foundation (to D.M.), the ERC ( BFU2015-70664-R and StG-281408 ) (to R.N.), and the NIH ( DK-21397 ) (to H.J.G.)
DS Minerva
RD 22 abr 2026