RT Journal Article
T1 Regulatory T cells modulate inflammation and reduce infarct volume in experimental brain ischaemia
A1 Brea López, David
A1 Agulla Freire, Jesús
A1 Rodríguez Yáñez, Manuel
A1 Barral, David
A1 Ramos Cabrer, Pedro
A1 Campos Pérez, Francisco
A1 Almeida, Ángeles
A1 Dávalos, Antoni
A1 Castillo Sánchez, José Antonio
K1 Cerebrovascular disease/stroke
K1 Regulatory T cells
K1 Inflammation
K1 Immunomodulation
AB Brain ischaemia (stroke) triggers an intense inflammatory response predominately mediated by the accumulation of inflammatory cells and mediators in the ischaemic brain. In this context, regulatory T (Treg) cells, a subpopulation of CD4+ T cells with immunosuppressive and anti‐inflammatory properties, are activated in the late stages of the disease. To date, the potential therapeutic usefulness of Treg cells has not been tested. In this study, we aimed to investigate whether Treg cells exert protection/repair following stroke. Both the adoptive transfer of Treg cells into ischaemic rats and the stimulation of endogenous T‐cell proliferation using a CD28 superagonist reduced the infarct size at 3–28 days following the ischaemic insult. Moreover, T cell‐treated animals had higher levels of FoxP3 and lower levels of IL‐1β, CD11b+ and CD68+ cells in the infarcted hemisphere when compared with control animals. However, T‐cell treatment did not alter the rate of proliferation of NeuN‐, NCAM‐ or CD31‐positive cells, thereby ruling out neurogenesis and angiogenesis in protection. These results suggest that adoptive transfer of T cells is a promising therapeutic strategy against the neurological consequences of stroke.
PB Wiley
YR 2014
FD 2014
LK http://hdl.handle.net/10347/21865
UL http://hdl.handle.net/10347/21865
LA eng
NO Brea, D., Agulla, J., Rodríguez‐Yáñez, M., Barral, D., Ramos‐Cabrer, P., Campos, F., Almeida, A., Dávalos, A. and Castillo, J. (2014), Regulatory T cells modulate inflammation and reduce infarct volume in experimental brain ischaemia. J. Cell. Mol. Med., 18: 1571-1579. doi:10.1111/jcmm.12304
NO Financial support from the Instituto de Salud Carlos III (projects PI11/02636and RETICS-INVICTUS R012/0014) of the Spanish Ministry of Economy and Competitiveness and the European Union (FEDER programme) is gratefullyacknowledged. Research contracts from the Miguel Servet programme (PRC)and the Sara Borrell programme (JA and D Brea) of the Instituto de Salud Carlos III are also acknowledged
DS Minerva
RD 23 abr 2026