RT Journal Article
T1 A Comprehensive Study on Tear Meniscus Height Inter-Eye Differences in Aqueous Deficient Dry Eye Diagnosis
A1 Sabucedo Villamarín, Belén
A1 Pena Verdeal, Hugo
A1 García Queiruga, Jacobo
A1 García Resúa, Carlos
A1 Giráldez Fernández, María Jesús
A1 Yebra-Pimentel Vilar, Eva
K1 Dry eye disease
K1 Tear meniscus height
K1 Aqueous deficient dry eye
K1 Diagnostic criteria
K1 Inter-eye differences
AB Background: Dry eye disease (DED) is a chronic ocular surface condition that requires precise diagnostic tools. The present study aimed to investigate the diagnostic potential of the absolute inter-eye difference (|OD-OS|) in tear meniscus height (TMH) for the detection of the presence of aqueous deficient dry eye (ADDE). Methods: A sample of 260 participants with dry eye complaints underwent ocular surface examinations thorough diagnostic assessments based on the Tear Film and Ocular Surface Society guidelines (TFOS DEWS II). Participants were subsequently categorized as No ADDE and ADDE based on TMH. Statistical analyses to determine the optimal TMH|OD-OS| cut-off value in a randomly selected study group (200 participants) were performed, while a separate validation analysis of the cut-off value obtained in a random cross-validation group (60 participants) was also performed. (3) Results: The significant diagnostic capability of TMH|OD-OS| (area under the curve = 0.719 ± 0.036, p < 0.001) was found. The identified cut-off value of 0.033 mm demonstrated reliable specificity (77.6%) and moderate sensitivity (59.1%). Cross-validation confirmed the cut-off value’s association with the TFOS DEWS II diagnostic criterion (Cramer’s V = 0.354, p = 0.006). (4) Conclusions: The present study provides evidence for the diagnostic potential of TMH|OD-OS| in identifying ADDE. The identified cut-off value enhances the specificity and offers moderate sensitivity, providing an objective tool for clinical decision making.
PB MDPI
YR 2024
FD 2024-01
LK http://hdl.handle.net/10347/32113
UL http://hdl.handle.net/10347/32113
LA eng
NO Pena-Verdeal, H.; Garcia-Queiruga, J.; Sabucedo-Villamarin, B.; Garcia-Resua, C.; Giraldez, M.J.; Yebra-Pimentel, E. A Comprehensive Study on Tear Meniscus Height Inter-Eye Differences in Aqueous Deficient Dry Eye Diagnosis. J. Clin. Med. 2024, 13, 659. https://doi.org/10.3390/jcm13030659
DS Minerva
RD 28 abr 2026