RT Journal Article
T1 Evaluation of differential effects of metformin treatment in obese children according to pubertal stage and genetic variations: study protocol for a randomized controlled trial
A1 Pastor Villaescusa, Belén
A1 Caballero Villarraso, Javier
A1 Cañete, M. Dolores
A1 Hoyos, Raúl
A1 Maldonado, José
A1 Bueno, Gloria
A1 Leis Trabazo, María Rosaura
A1 Cañete, Ramón
A1 Aguilera, Concepción M.
K1 Metformin
K1 Children
K1 Obesity
K1 Puberty
K1 Lifestyle intervention
K1 Microbiota
K1 Polymorphisms
AB Overweight and obesity are considered to be serious public health problems. In pediatric populations, insulin resistance, dyslipidemia, and hypertension associated with obesity occur with increased frequencies. Metformin is an oral anti-hyperglycemic agent that has been demonstrated to be efficacious in the treatment of diabetic and non-diabetic obese adults. A considerable amount of pharmacogenetic research has demonstrated that genetic variation is one of the major factors affecting metformin response. Additionally, potential microbiota-mediated mechanisms of metformin effect have been recently described. However, scant work has been conducted in children, with no attention being paid to the potential effects of pubertal development. Thus, the main objective of the present study is to evaluate the effect of metformin treatment together with lifestyle recommendations in a randomized control trial (RCT) of obese children according to pubertal stage, genetic variants and signature of gut microbiota
PB BioMed Central
SN 1745-6215
YR 2016
FD 2016-07-18
LK http://hdl.handle.net/10347/15918
UL http://hdl.handle.net/10347/15918
LA eng
NO Pastor-Villaescusa, Belén, Javier Caballero-Villarraso, M. Dolores Cañete, Raúl Hoyos, José Maldonado, Gloria Bueno, Rosaura Leis, Ángel Gil, Ramón Cañete, and Concepción M. Aguilera. 2016. "Evaluation Of Differential Effects Of Metformin Treatment In Obese Children According To Pubertal Stage And Genetic Variations: Study Protocol For A Randomized Controlled Trial". Trials 17 (1). doi:10.1186/s13063-016-1403-4
NO We would like to acknowledge the Spanish Ministry of Health, Social and Equality, General Department for Pharmacy and Health Products for financing this study; RETICS funded by the PN I + D + I 2008–2011 (Spain), ISCIII- Sub-Directorate General for Research Assessment and Promotion and The European Regional Development Fund (ERDF), Ref. Rd12/0026. Furthermore, the members of the project group who participate in the data and sample collection and the development of the FFQ (Miriam Latorre, PhD student, Pediatric Department, Lozano Blesa University Hospital, University of Zaragoza. Zaragoza, Spain; Rocío Vazquez-Cobela, PhD student, Unit of Investigation in Nutrition, Growth and Human Development of Galicia, Pediatric Department, Clinic University Hospital of Santiago, University of Santiago de Compostela. Santiago de Compostela, Spain). This paper will be part of María Belén Pastor Villaescusa’s doctorate, which is being performed within the “Nutrition and Food Sciences Program” at the University of Granada
DS Minerva
RD 28 abr 2026