RT Journal Article
T1 Remote Activation of Hollow Nanoreactors for Heterogeneous Photocatalysis in Biorelevant Media
A1 Sousa Castillo, Ana
A1 Rodríguez Couceiro, José
A1 Tomás Gamasa, María
A1 Mariño López, Andrea
A1 López García, Fernando
A1 Baaziz, Walid
A1 Ersen, Ovidiu
A1 Comesaña Hermo, Miguel
A1 Mascareñas Cid, José Luis
A1 Correa Duarte, Miguel Ángel
K1 Photocatalysis
K1 Bioorthogonal chemistry
K1 Plasmonic hot electrons
K1 Hybrid nanocapsules
AB Major current challenges in nano-biotechnology and nano-biomedicine include the implementation of predesigned chemical reactions in biological environments. In this context, heterogeneous catalysis is emerging as a promising approach to extend the richness of organic chemistry onto the complex environments inherent to living systems. Herein we report the design and synthesis of hybrid heterogeneous catalysts capable of being remotely activated by near-infrared (NIR) light for the performance of selective photocatalytic chemical transformations in biological media. This strategy is based on the synergistic integration of Au and TiO2 nanoparticles within mesoporous hollow silica capsules, thus permitting an efficient hot-electron injection from the metal to the semiconductor within the interior of the capsule that leads to a confined production of reactive oxygen species. These hybrid materials can also work as smart NIR-responsive nanoreactors inside living mammalian cells, a cutting-edge advance toward the development of photoresponsive theranostic platforms
PB American Chemical Society
SN 1530-6984
YR 2020
FD 2020
LK http://hdl.handle.net/10347/23536
UL http://hdl.handle.net/10347/23536
LA eng
NO Nano Lett. 2020, 20, 10, 7068–7076
NO This document is the Accepted Manuscript version of a Published Work that appeared in final form in Nano Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.nanolett.0c02180
NO This work was supported by the Ministerio de Economía y Competitividad (MINECO, Spain) under the Grant (CTM2017-84050-R, SAF2016-76689-R), Xunta de Galicia/FEDER (2015-CP082, ED431C 2017/19, IN607A 2018/5 and Centro Singular de Investigación de Galicia accreditation 2019–2022, ED431G 2019/06 and ED431G 2019/09), 0245_IBEROS_1_E, 0712_ACUINANO_1_E, 0624_2IQBIONEURO_6_E and NANOCULTURE cofounded by FEDER through the program Interreg V-A España-Portugal (POCTEP), NANOCULTURE (ERDF: 1.102.531) Interreg Atlantic Area, the European Union (European Regional Development Fund-ERDF), and the European Research Council (Advanced Grant No. 340055). M.T.-G. is thankful for the financial support from the Agencia Estatal de Investigación (RTI2018-093813-J-I00)
DS Minerva
RD 28 abr 2026