RT Dissertation/Thesis T1 Lifestyle and psychologic factors, and pain: a meta-analysis and cohort study A1 Karimi, Roya K1 Chronic pain K1 Alcohol K1 Quality of Life K1 Well-being K1 Cohort K1 Meta-analysis AB Chronic pain is one of the leading causes of healthcare seeking. It is amultidimensional experience affected by biological, physiological, psychological, social, and contextual factors. Inthis doctoral thesis, we conducted a dose-response meta-analysis to assess the effect of alcohol consumption onchronic pain. Also, we evaluated the direct and indirect effects of depression on pain through sleep disturbanceusing a two-stage meta-analytic structural equation modeling. Furthermore, we conducted a cohort study to assessthe impact of the health-related quality of life (well-being) on chronic pain incidence. Finally, we evaluated thecausal role of covariates in the association between physical well-being and chronic pain through mediationanalysis and stratum-specific analysis. YR 2023 FD 2023 LK http://hdl.handle.net/10347/30479 UL http://hdl.handle.net/10347/30479 LA eng DS Minerva RD 23 abr 2026