RT Journal Article
T1 Effects of intensity, attention and medication on auditory‑evoked potentials in patients with fibromyalgia
A1 Samartín Veiga, Noelia
A1 González Villar, Alberto Jacobo
A1 Triñanes Pego, Yolanda
A1 Gómez Perretta, Claudio
A1 Carrillo de la Peña, María Teresa
AB Fibromyalgia (FM) has been associated to an increased processing of somatosensory stimuli, but its generalization to other sensory modalities is under discussion. To clarify this, we studied auditory event-related potentials (AEPs) to stimuli of different intensity in patients with FM and healthy controls (HCs), considering the effects of attention mechanisms and medication. We performed two experiments: In study 1 (n = 50 FM, 60 HCs), the stimuli were presented randomly within the sequence; in study 2 (n = 28 FM, 30 HCs), they were presented in blocks of the same intensity. We analyzed intensity and group effects on N1-P2 amplitude and, only for the FM group, the effect of medication and the correlation between AEPs and clinical variables. Contrary to the expectation, the patients showed a trend of reduced AEPs to the loudest tones (study 1) or no significant differences with the HCs (study 2). Medication with central effects significantly reduced AEPs, while no significant relationships between the N1-P2 amplitude/intensity function and patients’ symptoms were observed. The findings do not provide evidence of augmented auditory processing in FM. Nevertheless, given the observed effect of medication, the role of sensory amplification as an underlying pathophysiological mechanism in fibromyalgia cannot be discarded
PB Springer Nature
YR 2020
FD 2020
LK http://hdl.handle.net/10347/27328
UL http://hdl.handle.net/10347/27328
LA eng
NO Samartin-Veiga, N., González-Villar, A. J., Triñanes, Y., Gómez-Perretta, C., & Carrillo-de-la-Peña, M. T. (2020). Efects of intensity, attention and medication on auditory evoked potentials in patients with fbromyalgia. Scientifc Reports, 10, Article 21904. https://doi.org/10.1038/s41598-020-78377-0
NO This study was supported by funding from from the Spanish Government (Ministerio de ciencia e Innovación; ref PSI2009-14555 and, Ministerio de Economía y Competitividad; ref PSI2013-45818-R) and from the Galician Government (Consellería de Cultura, Educación e Ordenación Universitaria; axudas para a consolidación e Estruturación de unidades de investigación competitivas do Sistema universitario de Galicia; grant number GPC 2014/047). A.G.V. was supported by a grant from the Portuguese Foundation for Science and Technology within the scope of the Individual Call to Scientific Employment Stimulus 2017. N.S.V. was supported by a grant from Spanish Government (Ministerio de Economía y Competitividad; grant number BES-2017-082684)
DS Minerva
RD 29 abr 2026