RT Dissertation/Thesis
T1 DNA recognition with self-assembled peptide helicates
A1 Gómez González, Jacobo
K1 metallopeptide
K1 DNA binding
K1 Self-assembly
AB Helicates, first described by Prof. Jean-Marie Lehn more than twenty years ago, display promising antimicrobial and antitumoral effects, but despite their compelling biological properties, the development of helicates into viable chemotherapeutic agents has been hampered by the lack of versatile and efficient stereoselective synthetic methods. In this thesis we describe the application of non-natural peptides containing the 2,2´-bipyridine ligand as platforms for the programmed self-assembly of DNA-binding metallopeptide helicates.
YR 2020
FD 2020
LK http://hdl.handle.net/10347/23305
UL http://hdl.handle.net/10347/23305
LA eng
DS Minerva
RD 30 abr 2026