RT Journal Article
T1 Advancing Diagnostics with Semi-Automatic Tear Meniscus Central Area Measurement for Aqueous Deficient Dry Eye Discrimination
A1 Pena Verdeal, Hugo
A1 García Queiruga, Jacobo
A1 Sabucedo Villamarín, Belén
A1 García Resúa, Carlos
A1 Giráldez Fernández, María Jesús
A1 Yebra-Pimentel Vilar, Eva
K1 Tear meniscus central area
K1 Aqueous deficient dry eye
K1 Tear film
K1 Diagnostic method
AB Background and Objectives: To clinically validate a semi-automatic measurement of Tear Meniscus Central Area (TMCA) to differentiate between Non-Aqueous Deficient Dry Eye (Non-ADDE) and Aqueous Deficient Dry Eye (ADDE) patients. Materials and Methods: 120 volunteer participants were included in the study. Following TFOS DEWS II diagnostic criteria, a battery of tests was conducted for dry eye diagnosis: Ocular Surface Disease Index questionnaire, tear film osmolarity, tear film break-up time, and corneal staining. Additionally, lower tear meniscus videos were captured with Tearscope illumination and, separately, with fluorescein using slit-lamp blue light and a yellow filter. Tear meniscus height was measured from Tearscope videos to differentiate Non-ADDE from ADDE participants, while TMCA was obtained from fluorescein videos. Both parameters were analyzed using the open-source software NIH ImageJ. Results: Receiver Operating Characteristics analysis showed that semi-automatic TMCA evaluation had significant diagnostic capability to differentiate between Non-ADDE and ADDE participants, with an optimal cut-off value to differentiate between the two groups of 54.62 mm2 (Area Under the Curve = 0.714 ± 0.051, p < 0.001; specificity: 71.7%; sensitivity: 68.9%). Conclusions: The semi-automatic TMCA evaluation showed preliminary valuable results as a diagnostic tool for distinguishing between ADDE and Non-ADDE individuals.
PB MDPI
YR 2025
FD 2025-07-23
LK https://hdl.handle.net/10347/42576
UL https://hdl.handle.net/10347/42576
LA eng
NO Pena-Verdeal, H.; Garcia- Queiruga, J.; Sabucedo-Villamarin, B.; Garcia-Resua, C.; Giraldez, M.J.; Yebra-Pimentel, E. Advancing Diagnostics with Semi-Automatic Tear Meniscus Central Area Measurement for Aqueous Deficient Dry Eye Discrimination. Medicina 2025, 61, 1322. hps://doi.org/ 10.3390/medicina61081322
DS Minerva
RD 30 abr 2026