RT Journal Article
T1 The role of extracellular vesicles in cellular senescence
A1 Estévez Souto, Valentín
A1 Silva Álvarez, Sabela da
A1 Collado Rodríguez, Manuel
K1 Cellular senescence
K1 EVs
K1 Extracellular vesicles
K1 Intercellular communication
AB Cellular senescence, an evolutionarily conserved mechanism that prevents the proliferation of damaged cells, is a very relevant cellular response involved in both physiological and pathological conditions. Even though senescent cells are stably growth arrested, they exhibit a complex and poorly understood secretory phenotype, known as senescence-associated secretory phenotype, composed of soluble proteins and extracellular vesicles (EVs). Extracellular vesicles were initially described as a waste management mechanism to remove damaged components of cellular metabolism, but increasing evidence shows that EVs could also play important roles in intercellular communication. Recently, some studies showed that EVs could have fundamental functions during cellular senescence. Our purpose in this review is to clarify the increasing literature on the role of EVs in cellular senescence as key mediators in cell-to-cell communication
PB Wiley
SN 1203–1211
YR 2022
FD 2022
LK http://hdl.handle.net/10347/30798
UL http://hdl.handle.net/10347/30798
LA eng
NO The FEBS Journal 290 (2023) 1203–1211. doi:10.1111/febs.16585
NO SDS-A is a postdoctoral fellow from GAIN, Xunta de Galicia (IN606B-2021/011). Work in the laboratory of MC is funded by grant RTI2018-095818-B-100 (MCINN/AEI/FEDER, UE) and IN60D 2021/08 (GAIN, Xunta de Galicia)
DS Minerva
RD 27 abr 2026