RT Journal Article
T1 Alzheimer’s disease seen through the eye: ocular alterations and neurodegeneration
A1 Romaus-Sanjurjo, Daniel
A1 Regueiro, Uxía 
A1 López López, Maite
A1 Vázquez Vázquez, Laura
A1 Ouro, Alberto
A1 Lema Gesto, María Isabel
A1 Sobrino, Tomás
K1 Alzheimer’s disease
K1 Amyloid burden
K1 Anterior segment
K1 Aqueous humor
K1 Biomarkers
K1 Cornea
K1 Tear fluid
K1 Tau
K1 Retina
K1 Posterior segment
AB Alzheimer’s Disease (AD) is one of the main neurodegenerative diseases worldwide. Unfortunately, AD shares many similarities with other dementias at early stages, which impedes an accurate premortem diagnosis. Therefore, it is urgent to find biomarkers to allow for early diagnosis of the disease. There is increasing scientific evidence highlighting the similarities between the eye and other structures of the CNS, suggesting that knowledge acquired in eye research could be useful for research and diagnosis of AD. For example, the retina and optic nerve are considered part of the central nervous system, and their damage can result in retrograde and anterograde axon degeneration, as well as abnormal protein aggregation. In the anterior eye segment, the aqueous humor and tear film may be comparable to the cerebrospinal fluid. Both fluids are enriched with molecules that can be potential neurodegenerative biomarkers. Indeed, the pathophysiology of AD, characterized by cerebral deposits of amyloid-beta (Aβ) and tau protein, is also present in the eyes of AD patients, besides numerous structural and functional changes observed in the structure of the eyes. Therefore, all this evidence suggests that ocular changes have the potential to be used as either predictive values for AD assessment or as diagnostic tools.
PB MDPI
SN 1661-6596
YR 2022
FD 2022-02-24
LK https://hdl.handle.net/10347/43944
UL https://hdl.handle.net/10347/43944
LA eng
NO Romaus-Sanjurjo, D.; Regueiro, U.; López-López, M.; Vázquez-Vázquez, L.; Ouro, A.; Lema, I.; Sobrino, T. Alzheimer’s Disease Seen through the Eye: Ocular Alterations and Neurodegeneration. Int. J. Mol. Sci. 2022, 23, 2486. https://doi.org/10.3390/ijms23052486
DS Minerva
RD 30 abr 2026