RT Dissertation/Thesis
T1 The sea lamprey GABAB receptor. Changes after spinal cord injury and its role in axonal regeneration
A1 Romaus-Sanjurjo, Daniel
K1 sea lamprey
K1 GABAB receptor
K1 spinal cord injury
K1 axonal regeneration
AB Spinal cord injury (SCI) causes irreversible loss of function. In contrast to mammals, lampreys show an amazing capacity for spontaneous recovery after a complete SCI. They provide an interesting model to understand the molecular processes that lead to spontaneous recovery. In this study, we analysed the changes in the expression of both gabab subunits after a complete SCI. Our results showed that plastic changes in this system probably contribute to the recovery of function after SCI in lampreys. Pharmacological and genetic manipulations revealed that endogenous GABA acting through GABAB receptors promotes axonal regeneration of descending neurons after a complete SCI in lampreys.
YR 2018
FD 2018
LK http://hdl.handle.net/10347/16702
UL http://hdl.handle.net/10347/16702
LA eng
DS Minerva
RD 23 abr 2026