RT Dissertation/Thesis
T1 Research and development of advanced controlled drug delivery systems: application in Keratoconus and Leber´s Hereditary Optic Neuropathy
A1 Varela Fernández, Rubén
K1 Keratoconus
K1 Leber's Hereditary Optic Neuropathy
K1 Nanoparticles
K1 Lactoferrin
K1 Intravitreal implant
K1 Controlled Drug Delivery
K1 Topical Ophthalmic administration
K1 Intravitreal administration
AB In the present thesis, the research, development, and characterizationprocesses of controlled drug delivery systems intended for the treatment of two different ocular pathologies weredescribed. Firstly, different types of lactoferrin-loaded nanoparticles intended for topical ophthalmic administrationwere developed and proposed as the first pharmacological alternative for the Keratoconus (KC) treatment. On theother hand, idebenone-loaded polymeric implants and microparticles were designed and proposed as newtherapeutic strategies for the treatment of Leber's Hereditary Optic Neuropathy (LHON).
YR 2022
FD 2022
LK http://hdl.handle.net/10347/28967
UL http://hdl.handle.net/10347/28967
LA eng
DS Minerva
RD 24 abr 2026