RT Journal Article
T1 Does the neuropsychiatric inventory predict progression from mild cognitive impairment to dementia? A systematic review and meta-analysis
A1 Mallo López, Sabela Carme
A1 Patten, Scott
A1 Ismail, Zahinoor
A1 Pereiro Rozas, Arturo X.
A1 Facal Mayo, David
A1 Otero Ortega, Carlos
A1 Juncos Rabadán, Onésimo
K1 Neuropsychiatric symptoms
K1 Mild cognitive impairment
K1 Dementia
K1 Neuropsychiatric inventory
K1 Neuropsychiatric inventory questionnaire
K1 Meta-analysis
AB BackgroundNeuropsychiatric Symptoms (NPS) are common in Mild Cognitive Impairment (MCI). The Neuropsychiatric Inventory (NPI) and its shorter version, the Neuropsychiatric Inventory Questionnaire (NPI-Q), are the most common measures to assess NPS. Our objective was to determine if NPI/NPI-Q ratings predict conversion from MCI to dementia.MethodsEmpirical longitudinal studies published in English or Spanish, concerned with the role of NPS as a risk factor for conversion from MCI to dementia, with a diagnosis of MCI following clinical criteria, that reported NPI/NPI-Q total score in converters versus non-converters, were included. Random effects models were used, and heterogeneity was explored with stratification and a random-effects meta-regression. The overall conversion rate and the standardized mean difference (SMD) for evolution, as a function of NPI/NPI-Q scores, were calculated.ResultsThe overall conversion rate was 35 %. Mean NPI/NPI-Q ratings were higher in converters versus in non-converters, with the overall SMD approaching significance. Heterogeneity was observed in studies of more than two years of follow-up and in a study with a mean age of more than 80 years. This heterogeneity concerned the size, not the direction of the difference.ConclusionsOur results suggest that NPI/NPI-Q ratings are associated with conversion from MCI to dementia
PB Elsevier
SN 1568-1637
YR 2020
FD 2020
LK http://hdl.handle.net/10347/32252
UL http://hdl.handle.net/10347/32252
LA eng
NO References  Mallo, S. C., Patten, S. B., Ismail, Z., Pereiro, A. X., Facal, D., Otero, C., & Juncos-Rabadán, O. (2020). Does the neuropsychiatric inventory predict progression from mild cognitive impairment to dementia? A systematic review and meta-analysis. Ageing Research Reviews, 58, 101004
NO This work was financially supported through FEDER founds by the Spanish Directorate General of Scientific and Technical Research (Project Ref. PSI2014-55316-C3-1-R), the National Research Agency (Spanish 'Ministry of Science, Innovation and Universities) (Project Ref. PSI2017-89389-C2-1-R) and by the Galician Government (Consellería de Cultura, Educación e Ordenación Universitaria; axudas para a consolidación e estruturación de unidades de investigación competitivas do Sistema Universitario de Galicia; GI-1807-USC: Ref. ED431-2017/27).
DS Minerva
RD 23 abr 2026