RT Journal Article
T1 Core-Shell Palladium/MOF Platforms as Diffusion-Controlled Nanoreactors in Living Cells and Tissue Models
A1 Martínez González, Raquel
A1 Carrillo Carrión, Carolina
A1 Destito, Paolo
A1 Álvarez Lorenzo, Aitor
A1 Tomás Gamasa, María
A1 Pelaz García, Beatriz
A1 López García, Fernando
A1 Mascareñas Cid, José Luis
A1 Pino González de la Higuera, Pablo Alfonso del
K1 Bioorthogonal chemistry
K1 Core-shell nanocomposite
K1 Nanoreactor
K1 Palladium
K1 ZIF-8
K1 MOF
K1 Intracellular catalysis
K1 Biocompatible organometallic catalyst
K1 Catalytic spheroid
K1 Diffusion-controlled reaction
AB Translating the potential of transition metal catalysis to biological and living environments promises to have a profound impact in chemical biology and biomedicine. A major challenge in the field is the creation of metal-based catalysts that remain active over time. Here, we demonstrate that embedding a reactive metallic core within a microporous metal-organic framework-based cloak preserves the catalytic site from passivation and deactivation, while allowing a suitable diffusion of the reactants. Specifically, we report the fabrication of nanoreactors composed of a palladium nanocube core and a nanometric imidazolate framework, which behave as robust, long-lasting nanoreactors capable of removing propargylic groups from phenol-derived pro-fluorophores in biological milieu and inside living cells. These heterogeneous catalysts can be reused within the same cells, promoting the chemical transformation of recurrent batches of reactants. We also report the assembly of tissue-like 3D spheroids containing the nanoreactors and demonstrate that they can perform the reactions in a repeated manner
PB Cell Press
SN 2666-3864
YR 2020
FD 2020
LK http://hdl.handle.net/10347/23205
UL http://hdl.handle.net/10347/23205
LA eng
NO Martínez et al., Cell Reports Physical Science 1, 100076
NO The authors thank the financial support of the MINECO ( CTQ2017-89588-R , SAF2016-76689-R , CTQ2017-84767-P , RYC-2014-16962 , and RYC-2017-23457 ), the Xunta de Galicia ( ED431F 2017/02 , 2015-CP082 , ED431C 2017/19 , and Centro singular de investigación de Galicia accreditation 2019-2022, ED431G 2019/03 ), the European Union (European Regional Development Fund [ERDF]; H2020-MSCA-IF-2016 grant agreement no. 749667 ; and INTERREG V-A Spain-Portugal [POCTEP] 2014-2020, project 0624_2IQBIONEURO_6_E ), and the European Research Council (advanced grant no. 340055 ). Support of the orfeo-cinqa network ( CTQ2016-81797-REDC ) is also kindly acknowledged
DS Minerva
RD 22 abr 2026