RT Journal Article
T1 Selective determination of sartan drugs in environmental water samples by mixed-mode solid-phase extraction and liquid chromatography tandem mass spectrometry
A1 Castro Varela, Gabriela
A1 Rodríguez Pereiro, Isaac
A1 Ramil Criado, María
A1 Cela Torrijos, Rafael
K1 Sartans
K1 Valsartan acid
K1 Mixed-mode solid-phase extraction
K1 Liquid chromatography tandem mass spectrometry
K1 Water analysis
AB Herein, a method for the simultaneous determination of the currently prescribed sartan drugs (eprosartan, EPR; olmesartan, OLM; losartan, LOS; candesartan, CAN; telmisartan, TEL; irbesartan, IRB; and valsartan, VAL), and the biodegradation product valsartan acid (VALA), in water samples (raw and treated wastewater, river and tap water) was developed. Solid-phase extraction (SPE) and ultra-performance liquid chromatography (UPLC) tandem mass spectrometry (MS/MS) were employed as concentration and determination techniques, respectively. Different sorbents and elution solvents were tested for sample preparation. Under optimized conditions, samples at neutral pH (6–8 units) were concentrated using mixed-mode (reversed-phase and anionic exchange) cartridges. Thereafter, the sorbent was washed with 5 mL of a methanol: water (1:1) solution, dried under a nitrogen stream and compounds were eluted with 2 mL of methanol: NH3 (98:2). The accuracy of the method (accounting for SPE efficiency and matrix effects during electrospray ionization) was investigated using solvent-based calibration standards. Global recoveries, obtained for different water matrices (tap, river, treated and raw wastewater), ranged from 82% to 134%, with standard deviations between 2 and 18%. LOQs varied from 2 to 50 ng L−1. Analysis of un-spiked samples confirmed: (1) the incomplete removal of sartans at sewage treatment plants (STPs), (2) the formation of VALA during municipal water treatment, and (3) the presence of VALA in the processed tap water samples. Additional findings of the current study are the detection of hydroxylated derivatives of the sartan drugs IRB and LOS in wastewater, and the E-Z isomerization of EPR in environmental water samples
PB Elsevier
SN 0045-6535
YR 2019
FD 2019
LK http://hdl.handle.net/10347/18412
UL http://hdl.handle.net/10347/18412
LA eng
NO Castro, G., Rodríguez, I., Ramil, M., & Cela, R. (2019). Selective determination of sartan drugs in environmental water samples by mixed-mode solid-phase extraction and liquid chromatography tandem mass spectrometry. Chemosphere, 224, 562-571. doi: 10.1016/j.chemosphere.2019.02.137
NO This is the accepted manuscript of the following article: Castro, G., Rodríguez, I., Ramil, M., & Cela, R. (2019). Selective determination of sartan drugs in environmental water samples by mixed-mode solid-phase extraction and liquid chromatography tandem mass spectrometry. Chemosphere, 224, 562-571. doi: 10.1016/j.chemosphere.2019.02.137
NO This study was supported by Xunta de Galicia (grant GRC-ED431C 2017/36), and the Spanish Government (grant CTQ2015-68660-P)
DS Minerva
RD 22 abr 2026