RT Journal Article
T1 Hypothalamic astrocytic-BMAL1 regulates energy homeostasis in a sex-dependent manner
A1 Luengo Mateos, María
A1 Gonzalez Vila, Antía
A1 Vicente Dragano, Nathalia Romanelli
A1 Ohinska, Nataliia
A1 Silveira Loureiro, María
A1 González Domínguez, Marco
A1 Estévez Salguero, Ánxela
A1 Novelle Rodriguez, Paula
A1 López Pérez, Miguel A.
A1 Barca Mayo, Olga
K1 Circadian clock
K1 Astrocytes
K1 Energy homeostasis
K1 Hypothalamus
K1 BMAL1
K1 Sexual dymorphism
AB Here, we demonstrate that hypothalamic astrocytic BMAL1 computes cyclic metabolic information to optimize energetic resources in a sexually dimorphic manner. Knockdown of BMAL1 in female astrocytes leads to negative energy balance and alters basal metabolic cycles without affecting circadian locomotor activity. Thus, astrocytic BMAL1 contributes to the control of energy balance through the modulation of the metabolic rate, hepatic and white adipose tissue lipogenesis, and the activity of brown adipose tissue. Importantly, most of these alterations are specific to hypothalamic astrocytic BMAL1. Moreover, female mice with BMAL1 knockdown in astrocytes exhibited a “male-like” metabolic obese phenotype when fed a high-fat diet. Overall, our results suggest a sexually dimorphic effect of astrocytic BMAL1 on the regulation of energy homeostasis, which may be of interest in the physiopathology of obesity and related comorbidities.
PB Elsevier
SN 2211-1247
YR 2023
FD 2023-08-29
LK https://hdl.handle.net/10347/38689
UL https://hdl.handle.net/10347/38689
LA eng
NO Luengo-Mateos, M., González Vila, A., Dragano, N.R.V., Ohinska, N., Silveira-Loureiro, M., González-Domínguez, M., Estévez-Salguero, A., Novelle-Rodríguez, P., López, M., Barca-Mayo, O. (2023). Hypothalamic astrocytic-BMAL1 controls energy balance in a sex-dependent manner. “Cell Reports”, vol. 42, 112949.
NO Xunta de Galicia (Consellería de Cultura, Educación e Ordenación Universitaria) (O.B.-M.: ED431F 2020/009); the Agencia Estatal de Investigación (O.B.-M.: PID2019-109556RB-I00); the Ministerio de Ciencia e Innovación (M.L.: PID2021-128145NB-I00 and PDC2022-133958- I00); the ‘‘la Caixa’’ Foundation (M.L.: ID 100010434); and Xunta de Galicia support for CiMUS (2016–2019, ED431G/05). O.B.-M. received a Ramón y Cajal award (RYC2018-026293-I) from the Spanish Ministerio de Ciencia, Innova- cio ´ n y Universidades. M.L.-M. and M.S.-L. are supported by the Ministerio de Ciencia, Innovación y Universidades of Spain (PRE2020-093614 and FPU2018/00647).
DS Minerva
RD 22 abr 2026