RT Journal Article
T1 Synthesis and structure-activity relationships of novel amino/nitro substituted 3-arylcoumarins as antibacterial agents
A1 Matos, Maria João Correia Pinto Carvalho de
A1 Vázquez Rodríguez, Saleta
A1 Santana Penín, María Lourdes
A1 Uriarte Villares, Eugenio
A1 Fuentes Edfuf, Cristina
A1 Santos Rodríguez, Ysabel
A1 Muñoz Crego, Ángeles
K1 Amino/nitro substituted 3-arylcoumarins
K1 Perkin reaction
K1 Antibacterial assays
K1 S. aureus
K1 E. coli
AB A new series of amino/nitro-substituted 3-arylcoumarins were synthesized and their antibacterial activity against clinical isolates of Staphylococcus aureus (Gram-positive) and Escherichia coli (Gram-negative) was evaluated. Some of these molecules exhibited antibacterial activity against S. aureus comparable to the standards used (oxolinic acid and ampicillin). The preliminary structure-activity relationship (SAR) study showed that the antibacterial activity against S. aureus depends on the position of the 3-arylcoumarin substitution pattern. With the aim of finding the structural features for the antibacterial activity and selectivity, in the present manuscript different positions of nitro, methyl, methoxy, amino and bromo substituents on the 3-arylcoumarin scaffold were reported
PB MDPI
YR 2013
FD 2013
LK http://hdl.handle.net/10347/23045
UL http://hdl.handle.net/10347/23045
LA eng
NO Matos, M.J.; Vazquez-Rodriguez, S.; Santana, L.; Uriarte, E.; Fuentes-Edfuf, C.; Santos, Y.; Muñoz-Crego, A. Synthesis and Structure-Activity Relationships of Novel Amino/Nitro Substituted 3-Arylcoumarins as Antibacterial Agents. Molecules 2013, 18, 1394-1404
NO Thanks are due to the Ministerio Español (PS09/00501), Xunta da Galicia (PGIDIT09CSA030203PR and PGIDT08MMA011200PR) and IN845B-2010/089 for the financial support. M.J.M. thanks to Fundação para a Ciência e Tecnologia for a PhD grant (SFRH/BD/61262/2009). S.V.R. thanks the Ministerio de Educación y Ciencia for a PhD grant (AP2008-04263)
DS Minerva
RD 23 abr 2026