RT Journal Article
T1 Correlation between Blunted Nocturnal Decrease in Diastolic Blood Pressure and Oxidative Stress: An Observational Study
A1 Vázquez Agra, Néstor
A1 Cruces Sande, Antón
A1 Méndez Álvarez, Estefanía
A1 Soto-Otero, Ramón
A1 Cinza Sanjurjo, Sergio
A1 López Paz, José Enrique
A1 Pose Reino, Antonio
A1 Hermida Ameijeiras, Álvaro
K1 Blood pressure
K1 Arterial hypertension
K1 Circadian profile
K1 Dipper
K1 Oxidative stress
K1 Thiobarbituric acid reactive substances
K1 Reduced thiols
AB An impaired nocturnal decrease in diastolic blood pressure (DBP) increases the blood pressure (BP) load, which is a main factor in endothelial dysfunction, atherosclerosis, and arterial stiffness. We aimed to quantify some markers of oxidative stress in hypertensive patients, to compare their levels between individuals with dipper and non-dipper DBP profiles, and to assess their correlation with the nocturnal DBP (nDBP) dipping. It was an observational study that included patients older than 18 years with a diagnosis of essential hypertension who consented to participate. The collected variables were some indices of 24-h ambulatory blood pressure monitoring, demographic, epidemiological, clinical, and laboratory variables. Plasma thiobarbituric acid reactive substances (TBARS) and reduced thiols, together with serum vitamin E, vitamin A, copper (Cu), and zinc (Zn) levels were assessed as oxidative stress markers. We recruited 248 patients with a median age of 56 years (56% women). The percentage of nDBP dipping showed a weak positive correlation with reduced thiol, vitamin E, and vitamin A levels; and a weak negative correlation with Cu levels. We also found a negative correlation between nDBP dipping and the TBARS/Thiol, TBARS/Vitamin E, and TBARS/Vitamin A ratios. After multivariate analysis, we found that increased TBARS/Thiol ratio and serum Cu levels were associated with a higher risk of a non-dipper DBP profile. As in other situations of increased cardiovascular risk, an impaired nDBP decrease may coincide with abnormalities in redox status
PB MDPI
YR 2022
FD 2022-12-09
LK https://hdl.handle.net/10347/38875
UL https://hdl.handle.net/10347/38875
LA eng
NO Vazquez-Agra, N., Cruces-Sande, A., Mendez-Alvarez, E., Soto-Otero, R., Cinza-Sanjurjo, S., Lopez-Paz, J.-E., Pose-Reino, A., & Hermida-Ameijeiras, A. (2022). Correlation between Blunted Nocturnal Decrease in Diastolic Blood Pressure and Oxidative Stress: An Observational Study. Antioxidants, 11(12), 2430. https://doi.org/10.3390/antiox11122430
DS Minerva
RD 28 abr 2026