RT Journal Article
T1 Predictors of Response to Exclusive Enteral Nutrition in Newly Diagnosed Crohn´s Disease in Children: PRESENCE Study from SEGHNP
A1 Moriczi, Melinda
A1 Pujol Muncunill, Gemma
A1 Martín Masot, Rafael
A1 Jiménez Treviño, Santiago
A1 Segarra Cantón, Oscar
A1 Ochoa Sangrador, Carlos
A1 Peña Quintana, Luís
A1 González Santana, Daniel
A1 Rodríguez Martínez, Alejandro
A1 Rosell Camps, Antonio
A1 Armas, Honorio
A1 Barrio, Josefa
A1 González de Caldas, Rafael
A1 Rodríguez Salas, Mónica
A1 Balmaseda Serrano, Elena
A1 Donat Aliaga, Ester
A1 Bodas Pinedo, Andrés
A1 Vaquero Sosa, Esther
A1 Vecino López, Raquel
A1 Solar Boga, Alfonso
A1 Moreno Álvarez, Ana
A1 Sánchez Sánchez, César
A1 Tolín Hernani, Mar
A1 Gutiérrez Junquera, Carolina
A1 Martinón Torres, Nazareth
A1 Leis Trabazo, María Rosaura
A1 Eizaguirre, Francisco Javier
A1 García Peris, Mónica
A1 Medina Benítez, Enrique
A1 Fernández Cebrián, Rafael
A1 Fernández Caamaño, Beatriz
A1 Vegas Álvarez, Ana María
A1 Crespo Valderrábano, Laura
A1 Alonso Vicente, Carmen
A1 Rubio Santiago, Javier
A1 Galera Martínez, Rafael
A1 García Romero, Ruth
A1 Ros Arnal, Ignacio
A1 Fernández Cebrián, Santiago
A1 Lorenzo Garrido, Helena
A1 Viada Bris, Javier Francisco
A1 Velasco Rodríguez-Belvís, Marta
A1 Bartolomé Porro, Juan Manuel
A1 Blanco Rodríguez, Miriam
A1 Barros García, Patricia
A1 Botija, Gonzalo
A1 Chicano Marín, Francisco José
A1 La Orden Izquierdo, Enrique
A1 Crehuá Gaudiza, Elena
A1 Navas López, Víctor Manuel
A1 Martín de Carpi, Javier
K1 Inflammatory bowel disease
K1 Crohn’s disease
K1 Exclusive enteral nutrition
K1 Calprotectin
K1 Children
K1 Paediatric
AB Exclusive enteral nutrition (EEN) has been shown to be more effective than corticosteroids in achieving mucosal healing in children with Crohn´s disease (CD) without the adverse effects of these drugs. The aims of this study were to determine the efficacy of EEN in terms of inducing clinical remission in children newly diagnosed with CD, to describe the predictive factors of response to EEN and the need for treatment with biological agents during the first 12 months of the disease. We conducted an observational retrospective multicentre study that included paediatric patients newly diagnosed with CD between 2014–2016 who underwent EEN. Two hundred and twenty-two patients (140 males) from 35 paediatric centres were included, with a mean age at diagnosis of 11.6 ± 2.5 years. The median EEN duration was 8 weeks (IQR 6.6–8.5), and 184 of the patients (83%) achieved clinical remission (weighted paediatric Crohn’s Disease activity index [wPCDAI] < 12.5). Faecal calprotectin (FC) levels (μg/g) decreased significantly after EEN (830 [IQR 500–1800] to 256 [IQR 120–585] p < 0.0001). Patients with wPCDAI ≤ 57.5, FC < 500 μg/g, CRP >15 mg/L and ileal involvement tended to respond better to EEN. EEN administered for 6–8 weeks is effective for inducing clinical remission. Due to the high response rate in our series, EEN should be used as the first-line therapy in luminal paediatric Crohn’s disease regardless of the location of disease and disease activity
PB MDPI
YR 2020
FD 2020
LK http://hdl.handle.net/10347/23884
UL http://hdl.handle.net/10347/23884
LA eng
NO Moriczi, M.; Pujol-Muncunill, G.; Martín-Masot, R.; Jiménez Treviño, S.; Segarra Cantón, O.; Ochoa Sangrador, C.; Peña Quintana, L.; González Santana, D.; Rodríguez Martínez, A.; Rosell Camps, A.; Armas, H.; Barrio, J.; González de Caldas, R.; Rodríguez Salas, M.; Balmaseda Serrano, E.; Donat Aliaga, E.; Bodas Pinedo, A.; Vaquero Sosa, E.; Vecino López, R.; Solar Boga, A.; Moreno Álvarez, A.; Sánchez Sánchez, C.; Tolín Hernani, M.; Gutiérrez Junquera, C.; Martinón Torres, N.; Leis Trabazo, M.R.; Eizaguirre, F.J.; García Peris, M.; Medina Benítez, E.; Fernández Caamaño, B.; Vegas Álvarez, A.M.; Crespo Valderrábano, L.; Alonso Vicente, C.; Rubio Santiago, J.; Galera-Martínez, R.; García-Romero, R.; Ros Arnal, I.; Fernández Cebrián, S.; Lorenzo Garrido, H.; Viada Bris, J.F.; Velasco Rodríguez-Belvis, M.; Bartolomé Porro, J.M.; Blanco Rodríguez, M.; Barros García, P.; Botija, G.; Chicano Marín, F.J.; La Orden Izquierdo, E.; Crehuá-Gaudiza, E.; Navas-López, V.M.; Martín-de-Carpi, J. Predictors of Response to Exclusive Enteral Nutrition in Newly Diagnosed Crohn´s Disease in Children: PRESENCE Study from SEGHNP. Nutrients 2020, 12, 1012
DS Minerva
RD 24 abr 2026