RT Journal Article
T1 The ββα fold of zinc finger proteins as a “natural” protecting group. Chemoselective synthesis of a DNA-binding zinc finger derivative
A1 Rodríguez Villar, Jéssica
A1 Mosquera Mosquera, Jesús
A1 Vázquez Vázquez, Olalla
A1 Vázquez Sentís, Marco Eugenio
A1 Mascareñas Cid, José Luis
AB We report the selective modification of cysteine residues engineered in peptides that have two additional cysteine residues as part of a Cys2His2 zinc finger motif. The chemoselective modification is achieved, thanks to the protecting effect exerted by the zinc cation upon coordination with the native cysteines and histidines of the zinc-finger fold. The strategy allows a straightforward synthesis of DNA binding zinc finger constructs
PB Royal Society of Chemistry
SN 1359-7345
YR 2014
FD 2014
LK http://hdl.handle.net/10347/18487
UL http://hdl.handle.net/10347/18487
LA eng
NO Rodríguez, J., Mosquera, J., Vázquez, O., Vázquez, M., & Mascareñas, J. (2014). The ββα fold of zinc finger proteins as a “natural” protecting group. Chemoselective synthesis of a DNA-binding zinc finger derivative. Chem. Commun.,50, 2258-2260. doi: 10.1039/c3cc47599a
NO We acknowledge the support from the Spanish grants SAF2010-20822-C02, CTQ2009-14431/BQU, CSD2007-00006, the Xunta de Galicia GRC2010/12, GRC2013-041 and INCITE09 209 084PR. J. R. thanks the Fundación Gil Dávila and the Xunta de Galicia and J. M. the Spanish MCINN for their PhD fellowships
DS Minerva
RD 24 abr 2026