RT Dissertation/Thesis
T1 Novel evidence for the role of monomeric C reactive protein and WISP2 in the modulation of catabolic and inflammatory response in cartilage and intervertebral disc
A1 Ruiz Fernández, Clara
K1 intervertebral disc degeneration
K1 osteoarthritis
K1 inflammation
K1 adipokines
K1 monomeric C reactive protein
AB Low back pain and osteoarthritis (OA) are the two mainmusculoskeletal diseases cause of disability worldwide, andintervertebral disc degeneration (IVDD) is considered the maincause of low back pain. A sustained inflammatory and catabolicstate has been related to the origin and progression of both, OAand IVDD.This research work introduces monomeric C reactive protein(mCRP) pro-inflammatory and catabolic effects in healthy anddegenerative human intervertebral disc cells and chondrocytes,suggesting its possible role in the pathophysiology of OA andIVDD. Furthermore, this thesis describes the adipokine WISP2relevant roles in modulating the turnover of extracellularmatrix in cartilage and how its downregulation maydetrimentally alter the inflammatory environment in OA joints.
YR 2023
FD 2023
LK http://hdl.handle.net/10347/31505
UL http://hdl.handle.net/10347/31505
LA eng
DS Minerva
RD 24 abr 2026