RT Journal Article
T1 Analysis of the vomeronasal organ transcriptome reveals variable gene expression depending on age and function in rabbits
A1 Rodríguez Villamayor, Paula
A1 Robledo Sánchez, Diego
A1 Fernández López, Carlos
A1 Gullón Álvarez, Julián
A1 Quintela Arias, Luis Ángel
A1 Sánchez Quinteiro, Pablo
A1 Martínez Portela, Paulino
K1 Vomeronasal organ
K1 Gene expression
K1 Age
K1 Sex
K1 VNO-receptors
K1 Rabbits
K1 RNA-Seq
AB The vomeronasal organ (VNO) is a chemosensory organ specialized in pheromone detection that shows a broad morphofunctional and genomic diversity among mammals. However, its expression patterns have only been well-characterized in mice. Here, we provide the first comprehensive RNA sequencing study of the rabbit VNO across gender and sexual maturation stages. We characterized the VNO transcriptome, updating the number and expression of the two main vomeronasal receptor families, including 128 V1Rs and 67 V2Rs. Further, we defined the expression of formyl-peptide receptor and transient receptor potential channel families, both known to have specific roles in the VNO. Several sex hormone-related pathways were consistently enriched in the VNO, highlighting the relevance of this organ in reproduction. Moreover, whereas juvenile and adult VNOs showed significant transcriptome differences, male and female did not. Overall, these results contribute to understand the genomic basis of behavioural responses mediated by the VNO in a non-rodent model
PB Elsevier
YR 2021
FD 2021
LK http://hdl.handle.net/10347/27675
UL http://hdl.handle.net/10347/27675
LA eng
NO Genomics 113 (2021) 2240-2252. https://doi.org/10.1016/j.ygeno.2021.05.007
DS Minerva
RD 23 abr 2026