RT Journal Article
T1 Developmental genoarchitectonics as a key tool to interpret the mature anatomy of the chondrichthyan hypothalamus according to the prosomeric model
A1 Santos Durán, Gabriel Nicolás
A1 Ferreiro Galve, Susana
A1 Mazan, Sylvie
A1 Anadón Álvarez, Ramón
A1 Rodríguez-Moldes Rey, María Isabel
A1 Candal Suárez, Eva María
K1 Catshark
K1 Scyliorhinus canicula
K1 Segmental
K1 Otp
K1 Dlx
K1 Pax6
K1 Pitx2
K1 5-HT
AB The hypothalamus is a key vertebrate brain region involved in survival and physiological functions. Understanding hypothalamic organization and evolution is important to deciphering many aspects of vertebrate biology. Recent comparative studies based on gene expression patterns have proposed the existence of hypothalamic histogenetic domains (paraventricular, TPa/PPa; subparaventricular, TSPa/PSPa; tuberal, Tu/RTu; perimamillary, PM/PRM; and mamillary, MM/RM), revealing conserved evolutionary trends. To shed light on the functional relevance of these histogenetic domains, this work aims to interpret the location of developed cell groups according to the prosomeric model in the hypothalamus of the catshark Scyliorhinus canicula, a representative of Chondrichthyans (the sister group of Osteichthyes, at the base of the gnathostome lineage). To this end, we review in detail the expression patterns of ScOtp, ScDlx2, and ScPitx2, as well as Pax6-immunoreactivity in embryos at stage 32, when the morphology of the adult catshark hypothalamus is already organized. We also propose homologies with mammals when possible. This study provides a comprehensive tool to better understand previous and novel data on hypothalamic development and evolution
PB Frontiers
SN 1662-5129
YR 2022
FD 2022
LK http://hdl.handle.net/10347/30192
UL http://hdl.handle.net/10347/30192
LA eng
NO Santos-Durán GN, Ferreiro-Galve S, Mazan S, Anadón R, Rodríguez-Moldes I and Candal E (2022) Developmental genoarchitectonics as a key tool to interpret the mature anatomy of the chondrichthyan hypothalamus according to the prosomeric model. Front. Neuroanat. 16:901451. doi: 10.3389/fnana.2022.901451
NO This work was supported by Ministerio de Economía, Industria y Competitividad – Agencia Estatal de Investigación (grant No. BFU2017-89861-P) partially financed by the European Social Fund, and by Xunta de Galicia (grant No. ED431C 2021/18)
DS Minerva
RD 23 abr 2026