RT Journal Article
T1 Maternal smoking in pregnancy and blood pressure during childhood and adolescence: a meta-analysis
A1 Mouriño Castro, Nerea
A1 Varela Lema, María Leonor
A1 Ahluwalia, Jasjit S.
A1 Rey Brandariz, Julia
A1 Candal Pedreira, Cristina
A1 Ruano Raviña, Alberto
A1 Vila Farinas, Andrea
A1 Torres, Andrés
A1 Pérez Ríos, Mónica
K1 Tobacco
K1 Pregnancy
K1 Blood pressure
K1 Meta-analysis
K1 Cohort studies
K1 Children
AB rterial hypertension during childhood or adolescence is rising, and smoking during pregnancy may constitute a modifiable risk factor. This study aims to evaluate the effect of maternal smoking during pregnancy on diastolic (DBP) and systolic blood pressure (SBP) in childhood and adolescence. A bibliographic search was conducted in PubMed, Embase, and CENTRAL databases in March 2022. Meta-analysis was performed with the difference in mean-adjusted SBP/DBP of children and adolescents aged 3–17 years, according to maternal smoking/non-smoking in pregnancy. A random effects model was applied; a leave-one-out analysis and meta-analysis by subgroups were performed. A modified Newcastle–Ottawa scale was used to assess the quality of the studies. Evidence levels were rated using the GRADE system. Fifteen studies were included in the meta-analysis; all of them evaluated the mean-adjusted SBP difference in children or adolescents (N = 73,448), and 6 also that of DBP (N = 31,459). Results showed that maternal smoking during pregnancy significantly increased SBP (β = 0.31 mmHg 95% CI 0.14–0.49). A greater increase in mean-adjusted SBP was observed in those studies that completed the recruitment before 1990, were conducted in non-European countries, used standard mercury or manual sphygmomanometry, adjusted for birth weight, and were in the lowest quality subgroup. No significant association was found for DBP. The GRADE level of evidence was low for SBP and very low for DBP. Conclusion: Smoking in pregnancy might increase SBP in childhood and adolescence. Due to the low level of evidence, solid inferences cannot be drawn about the clinical relevance of these findings.
PB Springer
SN 0340-6199
YR 2023
FD 2023
LK http://hdl.handle.net/10347/30370
UL http://hdl.handle.net/10347/30370
LA eng
NO Mourino, N., Varela-Lema, L., Ahluwalia, J.S. et al. Maternal smoking in pregnancy and blood pressure during childhood and adolescence: a meta-analysis. Eur J Pediatr (2023). https://doi.org/10.1007/s00431-023-04836-1
DS Minerva
RD 23 abr 2026