RT Journal Article
T1 Interleukin-10 facilitates the selection of patients for systemic thrombolysis
A1 Rodríguez Yáñez, Manuel
A1 Castellanos, Mar
A1 Sobrino Moreiras, Tomás
A1 Brea Floriani, José Manuel
A1 Ramos Cabrer, Pedro
A1 Pedraza, Salvador
A1 Castiñeiras, José A.
A1 Serena, Joaquín
A1 Dávalos, Antoni
A1 Castillo Sánchez, José Antonio
A1 Blanco González, Miguel
K1 Ischemic stroke
K1 Thrombolysis
K1 Interleukin-10
K1 MRI
AB BackgroundClinical-Diffusion mismatch (CDM; NIHSS score ≥8 & DWI lesion volume ≤25 mL) and Perfusion-Diffusion mismatch (PDM; difference >20% between initial DWI and MTT lesion volumes) have been proposed as surrogates for ischemic brains that are at risk of infarction. However, their utility to improve the selection of patients for thrombolytic treatment remains controversial. Our aim was to identify molecular biomarkers that can be used with neuroimaging to facilitate the selection of ischemic stroke patients for systemic thrombolysis.MethodsWe prospectively studied 595 patients with ischemic stroke within 12 h of the stroke onset. A total of 184 patients received thrombolytic treatment according to the SITS-MOST criteria. DWI and MTT volumes were measured at admission. The main outcome variable was good functional outcome at 3 months (modified Rankin scale <3). Serum levels of glutamate (Glu), IL-10, TNF-α, IL-6, NSE, and active MMP-9 also were determined at admission.ResultsPatients treated with t-PA who presented with PDM had higher IL-10 levels at admission (p < 0.0001). In contrast, patients with CDM had higher levels of IL-10 (p < 0.0001) as well as Glu and TNF-α (all p < 0.05) and lower levels of NSE and active MMP-9 (all p < 0.0001). IL-10 ≥ 30 pg/mL predicts good functional outcome at 3 months with a specificity of 88% and a sensitibity of 86%. IL-10 levels ≥30 pg/mL independently in both patients with PDM (OR, 18.9) and CDM (OR, 7.5), after an adjustment for covariates.ConclusionsSerum levels of IL-10 facilitate the selection of ischemic stroke patients with CDM and PDM for systemic thrombolysis.
PB BioMed Central
SN 1471-2377
SN 10.1186/1471-2377-13-62
YR 2013
FD 2013
LK http://hdl.handle.net/10347/23037
UL http://hdl.handle.net/10347/23037
LA eng
NO Rodríguez-Yáñez, M., Castellanos, M., Sobrino, T. et al. Interleukin-10 facilitates the selection of patients for systemic thrombolysis. BMC Neurol 13, 62 (2013). https://doi.org/10.1186/1471-2377-13-62
NO This project has been partially supported by grants from the Spanish Ministry of Science and Innovation (Fondo de Investigaciones Sanitarias, Instituto Salud Carlos III, RETICS-RD06/0026 and PI081472) and Xunta de Galicia (Consellería de Economía e Industria: 09CSA057918PR, Consellería de Sanidade: PS09/32)
DS Minerva
RD 22 abr 2026