RT Dissertation/Thesis
T1 Development and Evolution of the Vertebrate Hypothalamus: Evidences in Chondrichthyans
A1 Santos Durán, Gabriel Nicolás
A2 Universidade de Santiago de Compostela. Facultade de Bioloxía. Departamento de Bioloxía Celular e Ecoloxía, 
K1 hypothalamus
K1 Chondrichthyans
K1 evo-devo
K1 prosomeric model
K1 prosencephalon
AB The hypothalamus is a conserved integrative center with a complex organization result of a complex patterning processes. Here we make use of a evo-devo approach and the theoretical framework of the prosomeric model to understand the organization of the vertebrate hypothalamus. We studied the gene expression patterns of ScFoxg1a, ScDlx2/5, ScOtp, ScShh, ScNkx2.1, ScTbr1, ScNeurog2, ScLhx5, ScLhx9, ScDlx2/5, ScNkx2.8, ScEmx2, ScLmx1b, ScPitx2, ScPitx3a, ScNeurog2, ScFoxa1 and ScFoxa2 besides immunoreactivity to Pax6, PCNA and other immunomarkers in the embryonic hypothalamus and neighbour prosencephalic territories of a cartilaginous fish, the catshark, Scyliorhinus canicula. Our comparative analysis reveals the existence of conserved traits but also suggests an alternative organization to that proposed by the prosomeric model for the hypothalamus and even for the anterior prosencephalon of vertebrates.
YR 2016
FD 2016-03-08
LK http://hdl.handle.net/10347/13930
UL http://hdl.handle.net/10347/13930
LA eng
DS Minerva
RD 24 abr 2026