RT Journal Article
T1 Neuroanatomical and neurocognitive changes associated with subjective cognitive decline
A1 Rivas Fernández, Miguel Ángel
A1 Lindín, Mónica
A1 Zurrón, Montserrat
A1 Díaz Fernández, Fernando
A1 Lojo Seoane, Cristina
A1 Pereiro Rozas, Arturo X.
A1 Galdo Álvarez, Santiago
K1 Alzheimer’s disease
K1 Subjective cognitive decline (SCD)
K1 Structural magnetic resonance imaging
K1 Brain structural changes
K1 Subjective cognitive complaints
AB Introduction: Subjective Cognitive Decline (SCD) can progress to mild cognitiveimpairment (MCI) and Alzheimer’s disease (AD) dementia and thus may represent apreclinical stage of the AD continuum. However, evidence about structural changesobserved in the brain during SCD remains inconsistent.Materials and methods: This cross-sectional study aimed to evaluate, in subjectsrecruited from the CompAS project, neurocognitive and neurostructural differencesbetween a group of forty-nine control subjects and forty-nine individuals whomet the diagnostic criteria for SCD and exhibited high levels of subjectivecognitive complaints (SCCs). Structural magnetic resonance imaging was usedto compare neuroanatomical differences in brain volume and cortical thicknessbetween both groups.Results: Relative to the control group, the SCD group displayed structural changesinvolving frontal, parietal, and medial temporal lobe regions of critical importancein AD etiology and functionally related to several cognitive domains, includingexecutive control, attention, memory, and language.Conclusion: Despite the absence of clinical deficits, SCD may constitute a preclinicalentity with a similar (although subtle) pattern of neuroanatomical changes to thatobserved in individuals with amnestic MCI or AD dementia
PB Frontiers Media
YR 2023
FD 2023
LK http://hdl.handle.net/10347/30704
UL http://hdl.handle.net/10347/30704
LA eng
NO Rivas-Fernández MÁ, Lindín M, Zurrón M, Díaz F, Lojo-Seoane C, Pereiro AX and Galdo-Álvarez S (2023) Neuroanatomical and neurocognitive changes associated with subjective cognitive decline. Front. Med. 10:1094799
NO This study was supported by grants from the SpanishGovernment, Ministerio de Economía y Competitividad (PSI2014-55316-C3-3-R; PSI2017-89389-C2-2-R; and PID2020-114521RBC21/C22) and the Galician Government, Axudas para aConsolidación e Estruturación de Unidades de InvestigaciónCompetitivas do Sistema Universitario de Galicia: GRC (GI-1807-USC. Ref: ED431-2017/27 and ED431C-2021/04). All withERDF/FEDER funds
DS Minerva
RD 23 abr 2026