RT Journal Article
T1 In-situ particles reorientation during magnetic hyperthermia application: Shape matters twice
A1 Simeonidis, Konstantinos
A1 Morales, Maria del Puerto
A1 Marciello, Marzia
A1 ANGELAKERIS, MAKIS
A1 Presa, Patricia de la
A1 Lazaro-Carrillo, Ana
A1 Tabero, Andrea
A1 Villanueva, Angeles
A1 Chubykalo-Fesenko, Oksana
A1 Serantes Abalo, David
K1 Biological physics
K1 Magnetic materials
K1 Magnetic properties and materials
K1 Nanotechnology in cancer
AB Promising advances in nanomedicine such as magnetic hyperthermia rely on a precise control of thenanoparticle performance in the cellular environment. This constitutes a huge research challenge dueto difficulties for achieving a remote control within the human body. Here we report on the significantdouble role of the shape of ellipsoidal magnetic nanoparticles (nanorods) subjected to an externalAC magnetic field: first, the heat release is increased due to the additional shape anisotropy; second,the rods dynamically reorientate in the orthogonal direction to the AC field direction. Importantly,the heating performance and the directional orientation occur in synergy and can be easily controlledby changing the AC field treatment duration, thus opening the pathway to combined hyperthermic/mechanical nanoactuators for biomedicine. Preliminary studies demonstrate the high accumulationof nanorods into HeLa cells whereas viability analysis supports their low toxicity and the absence ofapoptotic or necrotic cell death after 24 or 48h of incubation
PB Nature Publishing Group
SN 2045-2322
YR 2016
FD 2016-12-06
LK http://hdl.handle.net/10347/16304
UL http://hdl.handle.net/10347/16304
LA eng
NO Simeonidis, K. et al. In-situ particles reorientation during magnetic hyperthermia application: Shape matters twice. Sci. Rep. 6, 38382; doi: 10.1038/srep38382 (2016)
DS Minerva
RD 29 abr 2026