RT Journal Article
T1 Size and Polarizability of Boron Cluster Carriers Modulate Chaotropic Membrane Transport
A1 Salluce, Giulia
A1 Folgar Cameán, Yeray
A1 Barba Bon, Andrea
A1 Nikšić Franjić, Ivana
A1 El Anwar, Suzan
A1 Grüner, Bohumír
A1 Lostalé Seijo, Irene
A1 Nau, Werner M.
A1 Montenegro García, Javier
K1 Boron
K1 Cluster compounds
K1 Peptide delivery
K1 Membranes
K1 Vesicles
AB Perhalogenated closo-borates represent a new class of membrane carriers. They owe this activity to their chaotropicity, which enables the transport of hydrophilic molecules across model membranes and into living cells. The transport efficiency of this new class of cluster carriers depends on a careful balance between their affinity to membranes and cargo, which varies with chaotropicity. However, the structure–activity parameters that define chaotropic transport remain to be elucidated. Here, we have studied the modulation of chaotropic transport by decoupling the halogen composition from the boron core size. The binding affinity between perhalogenated decaborate and dodecaborate clusters carriers was quantified with different hydrophilic model cargos, namely a neutral and a cationic peptide, phalloidin and (KLAKLAK)2. The transport efficiency, membrane-lytic properties, and cellular toxicity, as obtained from different vesicle and cell assays, increased with the size and polarizability of the clusters. These results validate the chaotropic effect as the driving force behind the membrane transport propensity of boron clusters. This work advances our understanding of the structural features of boron cluster carriers and establishes the first set of rational design principles for chaotropic membrane transporters
PB Wiley
SN 1433-7851
YR 2024
FD 2024-05-07
LK http://hdl.handle.net/10347/34843
UL http://hdl.handle.net/10347/34843
LA eng
NO Angew. Chem. Int. Ed. 2024, 63, e202404286
NO J.M. thanks the Spanish AEI (PCI2019-103400, PID2020-117143RB-I00), the Xunta de Galicia (Centro singular de investigación de Galicia accreditation 2019–2022, ED431G 2019/03, ED431F 2023/12, the Oportunius Program (GAIN)), Fundación la Caixa (TROPIC, HR23-00221), and the European Regional Development Fund (ERDF). G.S. and Y.F.-C. thank AEI for their predoctoral fellowships (PRE2018-085973; FPU21/04747); G.S. thanks Xunta de Galicia for her postdoctoral contract (ED481B-2023-123).A.B.-B. and W.M.N. thank the Deutsche Forschungsgemein schaft (DFG) for financial support through projects NA-868/14, NA-868/15 and NA-868/17; calculations were performedon a compute cluster funded by the DFG through project INST 676/7-1 FUGG. B.G. acknowledges financial support by the Czech Science Foundation through project No. 2114409S
DS Minerva
RD 23 abr 2026