RT Journal Article
T1 Light-Controlled Cellular Internalization and Cytotoxicity of Nucleic Acid-Binding Agents: Studies in Vitro and in Zebrafish Embryos
A1 Penas Tallón, Cristina
A1 Sánchez López, Mateo Isidro
A1 Guerra Varela, Jorge
A1 Sánchez Piñón, Laura
A1 Vázquez Sentís, Marco Eugenio
A1 Mascareñas Cid, José Luis
K1 DNA recognition
K1 Caged compounds
K1 Fluorescent probes
K1 Peptides
K1 Supramolecular chemistry
AB We synthesized octa‐arginine conjugates of DNA‐binding agents (bisbenzamidine, acridine and Thiazole Orange) and demonstrated that their DNA binding and cell internalization can be inhibited by appending a (negatively charged) oligoglutamic tail through a photolabile linker. UV irradiation released the parent conjugates, thus restoring cell internalization and biological activity. Assays with zebrafish embryos demonstrates the potential of this prodrug strategy for controlling in vivo cytotoxicity
PB Wiley
YR 2016
FD 2016
LK http://hdl.handle.net/10347/18485
UL http://hdl.handle.net/10347/18485
LA eng
NO C. Penas, M. I. Sánchez, J. Guerra-Varela, L. Sanchez, M. E. Vázquez, J. L. Mascareñas (2016). Light‐Controlled Cellular Internalization and Cytotoxicity of Nucleic Acid‐Binding Agents: Studies in Vitro and in Zebrafish Embryos. ChemBioChem, 17, 37-41. DOI: 10.1002/cbic.201500455
NO This is the peer reviewed version of the following article: C. Penas, M. I. Sánchez, J. Guerra-Varela, L. Sanchez, M. E. Vázquez, J. L. Mascareñas, ChemBioChem 2016, 17, 37-41, which has been published in final form at https://doi.org/10.1002/cbic.201500455. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions
NO We are thankful for the support given by the Spanish grants SAF2013–41943‐R, CTQ2012–31341 and CTQ2013–49317‐EXP, the Xunta de Galicia GRC2013–041, the ERDF and the European Research Council (Advanced Grant 340055). C.P. and M.I.S. thank the Spanish MCINN for their PhD fellowships
DS Minerva
RD 22 abr 2026