RT Journal Article
T1 Siderophores: Chemical tools for precise antibiotic delivery
A1 Rodríguez Lema, Diana
A1 González Bello, Concepción
K1 Iron scavenger
K1 Precise delivery
K1 Antibiotics
K1 Siderophore-antibiotic conjugate
K1 Iron transport-mediated delivery
AB The success of precision medicine coupled with the disappointing impact of broad-spectrum antibiotic use on microbiome stability and bacterial resistance, has triggered a shift in antibiotic design strategies toward precision antibiotics. This also includes the implementation of novel vectorization approaches directed to improve the internalization of antibacterial agents into deadly gram-negative pathogens through precise and well-defined mechanisms. The conjugation of antibiotics to siderophores (iron scavengers), which are compounds that are able to afford stable iron-complexes that facilitate the internalization into the cell by using bacterial iron uptake pathways as gateways, is a strategy that has begun to show excellent results with the commercialization of the first antibiotic based on this principle, cefiderocol. This digests review provides an overview of the molecular basis for this antibiotic-siderophore conjugation approach, along with recent successful examples and highlights future challenges facing this booming research area
PB Elsevier
YR 2023
FD 2023
LK http://hdl.handle.net/10347/30626
UL http://hdl.handle.net/10347/30626
LA eng
NO Bioorg. Med. Chem. Lett. 87 (2023) 129282
NO Financial support from the Spanish State Agency of Research (PID2019-105512RB-I00/AEI/10.13039/501100011033), the Xunta de Galicia [ED431C 2021/29 and Centro Singular de Investigación de Galicia Accreditation 2019-2022 (ED431G 2019/03)], and the European Regional Development Fund (ERDF) is gratefully acknowledged
DS Minerva
RD 22 abr 2026