RT Dissertation/Thesis
T1 Assembly of azaheterocycles via transition metal-catalyzed annulations involving the activation of C-H bonds
A1 Cendón Mariño, Borja
K1 Azaheterocyles
K1 Annulations
K1 Palladium
K1 Rhodium
K1 C-H Activation
AB Transition metal-catalyzed reactions initiated by the activation of C-H bondshave emerged as an especially attractive approach to assemble and modify a large number of compounds. In thiscontext, annulations are particularly interesting since they provide a straightforward approach to heterocyclicstructures from readily available precursors. In this PhD thesis, we describe our efforts towards the synthesis ofseveral highly appealing azaheterocycles through the metal-triggered activation of alkenyl and alkyl C-H bonds andannulation with unsaturated partners. Firstly, in chapter I, we descibe an unconventional annulation for thesynthesis of indoline scaffolds through a reaction between o-alkenylanilides and alkynes in presence of rhodiumcatalysis. Then, in chapter II, we show our attempts towards the synthesis of analogous aliphatic products,azepines, through the employment of homoallylamides as substrates. Finally, in chapter III, we assemble 2-piperidones by the use of alkyl amides and dienes as coupling partners via formal (4+2) cycloadditions in presenceof a palladium catalyst.
YR 2022
FD 2022
LK http://hdl.handle.net/10347/28936
UL http://hdl.handle.net/10347/28936
LA eng
DS Minerva
RD 25 abr 2026