RT Dissertation/Thesis
T1 Epigenetic modulation of the immune system in early childhood: from infectious diseases to vaccines
A1 Pischedda, Sara
K1 Epigenetics
K1 Immune System
K1 Childhood
K1 Infectious Diseases
K1 Vaccines
AB Epigenetic mechanisms regulate gene expression and transcription in a dynamic way. Many functional differences observed in the immune system of neonates and adults seem to be associated with epigenetic modifications of genes that control inflammation and immune response. One of the most studied epigenetic mechanisms is DNA methylation, considered as the major epigenetic factor influencing gene activities. Using the Infinium Illumina Methylation BeadChip platform it was possible to provide insights on the role of epigenetic mechanisms, especially DNA methylation alterations, in the different respiratory sequelae observed after RSV infection and in the variable immune response observed after PCV13 in early childhood.
YR 2021
FD 2021
LK http://hdl.handle.net/10347/26993
UL http://hdl.handle.net/10347/26993
LA eng
DS Minerva
RD 27 abr 2026