RT Journal Article
T1 Remodeling dental anatomy vs sham therapy for chronic temporomandibular disorders. A placebo-controlled randomized clinical trial
A1 Collier, Timothy
A1 Pocock, Stuart J.
A1 Lorenzo-Franco, Fernanda
A1 Varela Centelles, Pablo
A1 López-Cedrún, José
A1 Santana Penín, Urbano
A1 Santana Mora, Urbano
A1 López Solache, Alicia
A1 Mora Bermúdez, María Jesús
K1 Temporomandibular disorders (TMDs)
K1 Randomized clinical trial
K1 Evidence-based
K1 Orofacial pain
K1 Habitual chewing side
K1 Dental occlusion
K1 Occlusal equilibration
AB Background: Evidence regarding the etiology or effective treatments for chronic orofacial pain, the majority diagnosed as temporomandibular disorder (TMD), is limited. Purpose:To investigate whether occlusal equilibration therapy (ET) and decreasing the (higher) angle of the lateral guidance on the nonworking-side leads to a reduction in chronic TMDs intensity. Methods: It was conducted a randomized, explanatory, single blind with blinded assessment, placebo-controlled trial with strong protection against bias involving patients with chronic TMDs. Participants were randomly assigned to receive equilibration therapy or sham therapy. ET in this study consisted of minimal invasive occlusal remodeling to obtain balanced occlusion with reduction of the steeper angle of lateral mandibular movement with respect to the Frankfort plane. The primary outcome was a change in the pain intensity score (on a 0–10 point scale, with 0 indicating no pain and 10 the worst possible pain) at month 6. Secondary outcomes include maximum unassisted mouth opening and psychological distress. Results: A total of 77 participants underwent randomization, 39 of whom received ET and 38 sham therapy. The trial was stopped early for efficacy, according to preestablished rules when 67 participants (n = 34, n = 33, respectively) had completed the analysis. At month 6, the mean unadjusted pain intensity score was 2.1 in the ET and 3.6 in the sham therapy group (adjusted mean difference, −1.54; 95% confidence interval [CI] −0.5 to −2.6; P = 0.004; ANCOVA model). The mean increase in maximum unassisted mouth opening (main secondary outcome) was significantly higher in the real therapy group (adjusted mean difference 3.1 mm, 95% CI 0.5–5.7, p = 0.02). Conclusion: ET significantly reduced the intensity of facial pain associated with chronic TMDs and increased maximum unassisted mouth opening, as compared with sham therapy, over the course of 6 months. There were no serious adverse events.
PB Elsevier
SN 0940-9602
YR 2023
FD 2023-06-09
LK http://hdl.handle.net/10347/31014
UL http://hdl.handle.net/10347/31014
LA eng
NO Annals of Anatomy 250 (2023) 152117
NO This study was financially supported by the Instituto de Salud Carlos III from the Ministry of Science and Innovation of the Government of Spain and European Regional Development Fund, Grant nº PI11/02507; “una manera de hacer Europa.”
DS Minerva
RD 27 abr 2026