RT Dissertation/Thesis
T1 Relation of exposure to secondhand tobacco smoke during pregnancy and early childhood with adolescents body composition and cardiometabolic health: a cohort study
A1 Mouriño Castro, Nerea
K1 secondhand tobacco smoke
K1 cotinine
K1 reference value
K1 children
K1 adolescents
K1 body composition
K1 cardiometabolic risk factors
AB Exposure to secondhand tobacco smoke (SHS) is a worldwide public healthproblem and children are a particularly vulnerable population due to their anatomical, physiological, and behavioralcharacteristics. Cotinine concentrations in saliva, blood, and hair have become the most widely used biomarkers ofSHS in children. Currently, there is no consensus regarding the optimal cut-point for the classification of SHSexposure among young children. Indeed, the systematic review conducted as part of this thesis shows that serumcotinine cut-points have varied remarkably since 1985 and across the countries; the most recently used cut-point toassess SHS exposure in US children has been 0.015 ng/mL, which derives from the assay limit of detection (LOD)used by the National Health and Nutrition Examination Survey (NHANES). Considering that cotinine metabolismand clearance may vary by age, and that childrens physiology is quite different within the 0-5 years old age range,age-specific cut-points could be useful to accurately classify nonsmoking children as exposed or unexposed to SHSin a standardized manner.This thesis includes the first study estimating age-specific cut-points to classify SHS exposure among childrenunder 5 years old. Interestingly, when applying these serum cotinine cut-points, compared to the assay LODderived cut-point, results showed that prevalence of childrens SHS exposure declined at all ages, and thatconcordance between mother-reported SHS exposure and childrens serum cotinine improved considerably.
YR 2022
FD 2022
LK http://hdl.handle.net/10347/29931
UL http://hdl.handle.net/10347/29931
LA eng
DS Minerva
RD 23 abr 2026