RT Journal Article
T1 Glial Bmal1 role in mammalian retina daily changes
A1 Riccitelli, Serena
A1 Boi, Fabio
A1 Lonardoni, Davide
A1 Giantomasi, Lidia
A1 Barca Mayo, Olga
A1 De Pietri Tonelli, Davide
A1 Bisti, Silvia
A1 Di Marco, Stefano
A1 Berdondini, Luca
K1 Circadian clock
K1 Astrocytes
K1 Retina
K1 BMAL1
AB Visual information processing in the retina requires the rhythmic expression of clock genes. The intrinsic retinal circadian clock is independent of the master clock located in the hypothalamic suprachiasmatic nucleus and emerges from retinal cells, including glia. Less clear is how glial oscillators influence the daily regulation of visual information processing in the mouse retina. Here, we demonstrate that the adult conditional deletion of the gene Bmal1 in GLAST-positive glial cells alters retinal physiology. Specifically, such deletion was sufficient to lower the amplitude of the electroretinogram b-wave recorded under light-adapted conditions. Furthermore, recordings from > 20,000 retinal ganglion cells (RGCs), the retina output, showed a non-uniform effect on RGCs activity in response to light across different cell types and over a 24-h period. Overall, our results suggest a new role of a glial circadian gene in adjusting mammalian retinal output throughout the night-day cycle.
PB Nature
SN 2045-2322
YR 2022
FD 2022-12-13
LK https://hdl.handle.net/10347/38688
UL https://hdl.handle.net/10347/38688
LA eng
NO Riccitelli, S., Boi, F., Lonardoni, D., Giantomasi, L., Barca-Mayo, O., De Pietri Tonelli, D., Bisti, S., Di Marco, S., Berdondini, L. (2022). Glial Bmal1 role in mammalian retina daily changes. "Scientific Reports", 12, 21561
NO European Research Executive Agency (REA) through the FP7- PEOPLE-2014-IEF “ASTROCLOCK” (629867) and Fondazione CARIPLO research grant (2015-0590).
DS Minerva
RD 28 abr 2026