RT Journal Article
T1 Resting state electroencephalographic rhythms are affected by immediately preceding memory demands in cognitively unimpaired elderly and patients with mild cognitive impairment
A1 Fernández, Alba
A1 Noce, Giuseppe
A1 Percio, Claudio del
A1 Pinal, Diego
A1 Díaz Fernández, Fernando
A1 Lojo Seoane, Cristina
A1 Zurrón, Montserrat
A1 Babiloni, Claudio
K1 Resting state EEG power
K1 Alpha oscillations
K1 Cortical arousal
K1 Mild cognitive impairment
K1 Cognitive engagement
K1 Memory
K1 Aging
AB Experiments on event-related electroencephalographic oscillations in agedpeople typically include blocks of cognitive tasks with a few minutes ofinterval between them. The present exploratory study tested the effect ofbeing engaged on cognitive tasks over the resting state cortical arousalafter task completion, and whether it differs according to the level of theparticipant’s cognitive decline. To investigate this issue, we used a localdatabase including data in 30 healthy cognitively unimpaired (CU) personsand 40 matched patients with amnestic mild cognitive impairment (aMCI).They had been involved in 2 memory tasks for about 40 min and underwentresting-state electroencephalographic (rsEEG) recording after 5 min from thetask end. eLORETA freeware estimated rsEEG alpha source activity as anindex of general cortical arousal. In the CU but not aMCI group, there wasa negative correlation between memory tasks performance and posteriorrsEEG alpha source activity. The better the memory tasks performance,the lower the posterior alpha activity (i.e., higher cortical arousal). Therewas also a negative correlation between neuropsychological test scores ofglobal cognitive status and alpha source activity. These results suggest thatengagement in memory tasks may perturb background brain arousal formore than 5 min after the tasks end, and that this effect are dependent on participants global cognitive status. Future studies in CU and aMCI groups maycross-validate and extend these results with experiments including (1) rsEEGrecordings before memory tasks and (2) post-tasks rsEEG recordings after 5,15, and 30 min
SN 1663-4365
YR 2022
FD 2022
LK http://hdl.handle.net/10347/29963
UL http://hdl.handle.net/10347/29963
LA eng
NO Fernández A, Noce G, Del Percio C, Pinal D, Díaz F, Lojo-Seoane C, Zurrón M and Babiloni C (2022) Resting state electroencephalographic rhythms are affected by immediately preceding memory demands in cognitively unimpaired elderly and patients with mild cognitive impairment. Front. Aging Neurosci. 14:907130
NO This study was supported by grants from the Spanish Government, Ministerio de Ciencia e Innovación (PSI2017-89389-C2-R and PID2020-114521RB-C21/C22); the Galician Government (Xunta de Galicia), Axudas para a Consolidación e Estruturación de Unidades de Investigación Competitivas do Sistema Universitario de Galicia: GRC (GI-1807- USC); Ref: ED431-2017/27 and ED431C-2021/04; all with ERDF/FEDER funds. DP was supported by the Fundação para a Ciência e a Tecnologia (FCT) grant with reference SFRH/BPD/120111/2016. AF was supported by an FPI grant from the Ministerio de Ciencia e Innovación with reference PRE2018-085514
DS Minerva
RD 23 abr 2026