RT Journal Article T1 How Safe Is Safe for Marine Toxins Monitoring? A1 Botana López, Luis Miguel A1 Alfonso Rancaño, María Amparo A1 Rodríguez Filgueiras, Inés A1 Botana López, Ana María A1 Louzao Ojeda, María del Carmen A1 Rodríguez Vieytes, Mercedes K1 Food safety K1 Toxicity equivalency factor K1 Mass spectrometry K1 Monitoring K1 Marine toxin AB Current regulation for marine toxins requires a monitoring method based on mass spectrometric analysis. This method is pre-targeted, hence after searching for pre-assigned masses, it identifies those compounds that were pre-defined with available calibrants. Therefore, the scope for detecting novel toxins which are not included in the monitoring protocol are very limited. In addition to this, there is a poor comprehension of the toxicity of some marine toxin groups. Also, the validity of the current approach is questioned by the lack of sufficient calibrants, and by the insufficient coverage by current legislation of the toxins reported to be present in shellfish. As an example, tetrodotoxin, palytoxin analogs, or cyclic imines are mentioned as indicators of gaps in the system that require a solid comprehension to assure consumers are protected PB MDPI AG YR 2016 FD 2016-07-06 LK http://hdl.handle.net/10347/16250 UL http://hdl.handle.net/10347/16250 LA eng NO Botana, L.M.; Alfonso, A.; Rodríguez, I.; Botana, A.M.; Louzao, M.C.; Vieytes, M.R. How Safe Is Safe for Marine Toxins Monitoring? Toxins 2016, 8, 208 NO The research leading to these results has received funding from the following FEDERcofunded-grants. From Centro Desarrollo Tecnológico e Industrial (CDTI), supported by Ministerio deEconomía y Competitividad, AGL2012-40185-CO2-01, AGL2014-58210-R, and Consellería de Cultura, Educacióne Ordenación Universitaria, GRC2013-016. From CDTI under ISIP Programme, Spain, IDI-20130304 APTAFOOD.From the European Union’s Seventh Framework Programme managed by REA—Research Executive Agency(FP7/2007–2013) under grant agreement 312184 PHARMASEA DS Minerva RD 6 jun 2026