RT Journal Article
T1 Sponges containing tetracycline loaded-PLGA-zein microparticles as a periodontal controlled release device
T2 Sponges containing tetracycline loaded-microparticles for periodontal use
A1 Sousa, Francisco F.O.
A1 Luzardo Álvarez, Asteria María
A1 Pérez-Estévez, Antonio
A1 Seoane Prado, Rafael
A1 Blanco Méndez, José
K1 Sponges
K1 Controlled release
K1 Microparticles
K1 Antimicrobial
K1 Tetracycline
K1 Periodontal
AB This paper aimed to design collagen sponges containing tetracycline-loaded PLGA-zein microparticles with controlled release characteristics as an alternative for periodontal treatment. Tetracycline microparticles were prepared by spray-drying technique, while the sponges were prepared by their dispersion in collagen suspension and subsequent freeze-drying. Release studies of two microparticles compositions loaded and unloaded-collagen sponges were carried over a 10 days period. Antibiogram tests were used to ensure the sustained antibacterial activity against Staphylococcus aureus. SEM imagens demonstrated spherical and non-aggregated microparticles (2–5 μm) and their effective dispersion within the sponges, what together with the pronounced water sorption promoted by the collagen fibers enhanced the drug release from the unitary particles. The dissolution profiles showed a sustained-release pattern for both sponges and microparticles formulations, reaching in some cases almost the complete drug recovery. The sponge formulations increased the release of tetracycline up to 45 and 60% in the first 12 h, while their microparticles pairs released less than 30 and 10%, respectively, as a result of their aggregation. Antibiograms showed that the sponges sustained released tetracycline over 10 days and could represent an alternative for periodontal insertion as well as for those applications where the prevention and control of bacterial infections is needed. The incorporation of tetracycline microparticles to collagen sponges improved the release rates of this antimicrobial agent and therefore represents an alternative for controlled antimicrobial activity.
PB Elsevier
SN 1773-2247
YR 2020
FD 2020-05-20
LK https://hdl.handle.net/10347/39089
UL https://hdl.handle.net/10347/39089
LA eng
NO Journal of Drug Delivery Science and Technology Volume 59, October 2020, 101858
NO Coordenação de Aperfeiçoamento de Pessoal de Nível Superior ‐ Brasil (CAPES) ‐ National Program of Cooperation in the Amazon – PROCAD/Amazon of Coordination of Superior Level Staff Improvement–CAPES/Brazil.
DS Minerva
RD 23 abr 2026