RT Journal Article
T1 Tobacco Patterns and Risk of Chronic Obstructive Pulmonary Disease: Results From a Cross-Sectional Study
A1 Rey Brandariz, Julia
A1 Pérez-Ríos, Mónica
A1 Ahluwalia, Jasjit S.
A1 Beheshtian, Kiana
A1 Fernández-Villar, Alberto
A1 Represas-Represas, Cristina
A1 Piñeiro, María
A1 Alfageme, Inmaculada
A1 Ancochea, Julio
A1 Soriano, Joan B.
A1 Casanova, Ciro
A1 Cosío, Borja G.
A1 García-Río, Francisco
A1 Miravitlles, Marc
A1 de Lucas, Pilar
A1 Rodríguez González-Moro, José Miguel
A1 Soler-Cataluña, Juan José
A1 Ruano Raviña, Alberto
K1 Pulmonary disease
K1 Chronic obstructive
K1 Tobacco
K1 Cross-sectional
K1 EPISCAN-II
AB IntroductionThere is still uncertainty about which aspects of cigarette smoking influence the risk of Chronic Obstructive Pulmonary Disease (COPD). The aim of this study was to estimate the COPD risk as related to duration of use, intensity of use, lifetime tobacco consumption, age of smoking initiation and years of abstinence.MethodsWe conducted an analytical cross-sectional study based on data from the EPISCAN-II study (n = 9092). All participants underwent a face-to-face interview and post-bronchodilator spirometry was performed. COPD was defined as post-bronchodilator FEV1/FVC < 70%. Parametric and nonparametric logistic regression models with generalized additive models were used.Results8819 persons were included; 858 with COPD and 7961 without COPD. The COPD risk increased with smoking duration up to ≥50 years [OR 3.5 (95% CI: 2.3–5.4)], with smoking intensity up to ≥39 cig/day [OR 10.1 (95% CI: 5.3–18.4)] and with lifetime tobacco consumption up to >29 pack-years [OR 3.8 (95% CI: 3.1–4.8)]. The COPD risk for those who started smoking at 22 or later was 0.9 (95% CI: 0.6–1.4). The risk of COPD decreased with increasing years of cessation. In comparison with both never smokers and current smokers, the lowest risk of COPD was found after 15–25 years of abstinence.ConclusionCOPD risk increases with duration, intensity, and lifetime tobacco consumption and decreases importantly with years of abstinence. Age at smoking initiation shows no effect. After 15–25 years of cessation, COPD risk could be equal to that of a never smoker. This work suggests that the time it takes to develop COPD in a smoker is about 30 years
PB Elsevier
SN 0300-2896
YR 2023
FD 2023-07-14
LK http://hdl.handle.net/10347/31151
UL http://hdl.handle.net/10347/31151
LA eng
NO Archivos de Bronconeumología 59 (2023) 717–724
NO The EPISCAN II study was funded and sponsored by GlaxoSmithKline, Spain through an unrestricted grant. The EPISCAN II study is registered in ClinicalTrial.gov under registry number: NCT01122758. Dr. Ahluwalia funded in part by P20GM130414, a NIH funded Center of Biomedical Research Excellence (COBRE). The sponsors were not involved in study design, data collection, analysis and interpretation, or original report writing
DS Minerva
RD 22 abr 2026