RT Journal Article T1 8-Propyl-6H-[1,3]dioxolo[4,5-g]chromen-6-one: A new coumarin with monoamine oxidase B inhibitory activity and possible anti-parkinsonian effects A1 Pilar Olaya, María del A1 Vergel, Nadezdha Esperanza A1 López, Jose Luis A1 Viña Castelao, María Dolores K1 Parkinson’s disease K1 Monoamine oxidase B K1 Coumarin K1 Mice K1 Reserpine K1 Levodopa K1 Carbidopa AB Parkinson’s disease is a common neurodegenerative disorder. In this study, the monoamine oxidase inhibitory activity and potential anti-parkinsonian effects of 8-propyl-6H-[1,3]dioxolo[4,5-g]chromen-6-one (FCS303), a new synthetic coumarin, were evaluated. To do this, we used the reserpine model of Parkinson’s disease, an assay of levodopa/carbidopa potentiation, the catalepsy model of haloperidol, and an in vitro assay against monoamine oxidase (MAO) activity. Additionally, lipid peroxidation and protein carbonyl group quantification was performed in mice brain homogenates previously treated with haloperidol. FCS303 inhibited monoamine oxidase B (MAO-B) with an IC50 of 5.46 ± 0.36 µM; however, there was no effect on monoamine oxidase A (MAO-A). The oral administration of FCS303 led to a significant reversal of hypokinesia in the reserpine model (at 24 h, doses of 100 and 200 mg/kg) and in the levodopa/carbidopa potentiation assay (at 2 and 24 h, dose of 200 mg/kg). In addition, FCS303 (100 mg/kg) showed anti-cataleptic activity against haloperidol. FCS303 (50 mg/kg) significantly decreased lipid peroxidation and protein carbonyl quantification. These results suggest that FCS303 could present anti-parkinsonian activity related to MAO-B inhibitory activity. PB Universidade de São Paulo SN 1984-8250 YR 2020 FD 2020 LK http://hdl.handle.net/10347/21693 UL http://hdl.handle.net/10347/21693 LA eng NO OLAYA, María del Pilar et al. 8-Propyl-6H-[1,3]dioxolo[4,5-g]chromen-6-one: A new coumarin with monoamine oxidase B inhibitory activity and possible anti-parkinsonian effects. Braz. J. Pharm. Sci. [online]. 2020, vol.56 [cited 2020-04-23], e17609. Available from: . Epub Mar 16, 2020. ISSN 2175-9790. https://doi.org/10.1590/s2175-97902019000317609 NO This work was conducted with funding from Universidad Nacional de Colombia, Bogotá (VRI/DIB, Project: 13668) DS Minerva RD 24 abr 2026