RT Journal Article
T1 Soluble CD26 Levels and Its Association to Epidemiologic Parameters in a Sample Population
A1 Chiara, Loretta De
A1 Rodríguez Piñeiro, Ana M.
A1 Cordero Santamaría, Óscar Javier
A1 Rodríguez Berrocal, Francisco Javier
A1 Ayude, Daniel
A1 Rivas Hervada, Francisco J.
A1 Páez de la Cadena, María
K1 sCD26
K1 Serum levels
K1 Colorectal cancer
K1 Digestive pathologies
K1 Marker
AB Introduction: Previous studies have suggested the use of soluble CD26 (sCD26) as a tumour marker for the detectionof colorectal cancer (CRC) and advanced adenomas. The aim of this study was to assess the sCD26 concentration in a largecohort to evaluate its association to epidemiologic parameters and CRC-related symptoms/pathologies.Subjects and methods: Serum samples were collected from 2,754 putatively healthy individuals with ages ranging from 30–65years, and with personal or familial history of polyps, CRC and/or CR symptoms. sCD26 levels were measured by ELISA.Results: No association was found between the sCD26 concentration and age (< 50 and   50), the personal or familialhistory of polyps or CRC, rectal bleeding, haemorrhoids or diverticula. However, sCD26 was related to non-inflammatorybenign pathologies (excluding rectal bleeding, changes in bowel habits, haemorrhoids, diverticula) and to inflammatory benignpathologies.Discussion: Our results confirm that the sCD26 can be easily offered and evaluated in a large cohort. Additionally, the validation ofsCD26 as a tumour marker for screening and case-finding purposes requires a further comparison with an established non-invasivetest like the faecal occult blood.
PB Hindawi
SN 0278-0240
YR 2009
FD 2009
LK http://hdl.handle.net/10347/22705
UL http://hdl.handle.net/10347/22705
LA eng
NO Chiara, L.D., Rodríguez-Piñeiro, A.M., Cordero, O.J. et al. (2009). Soluble CD26 Levels and Its Association to Epidemiologic Parameters in a Sample Population, "Disease Markers", 27, 311–316
DS Minerva
RD 22 abr 2026