RT Journal Article
T1 A mathematical model of dynamics of cell populations in squamous epithelium after irradiation
A1 Paga Pazos, Martín
A1 López Pouso, Óscar
A1 Fenwick, John D.
A1 Pardo Montero, Juan
K1 Biomathematical model
K1 Radiotherapy
K1 Mucositis
K1 Radiobiology
AB PurposeTo develop multi-compartment mechanistic models of dynamics of stem and functional cell populations in epithelium after irradiation.Methods and materials: We present two models, with three (3C) and four (4C) compartments respectively. We use delay differential equations, and include accelerated proliferation, loss of division asymmetry, progressive death of abortive stem cells, and turnover of functional cells. The models are used to fit experimental data on the variations of the number of cells in mice mucosa after irradiation with 13 Gy and 20 Gy. Akaike information criteria (AIC) was used to evaluate the performance of each model.ResultsBoth 3C and 4C models provide good fits to experimental data for 13 Gy. Fits for 20 Gy are slightly poorer and may be affected by larger uncertainties and fluctuations of experimental data. Best fits are obtained by imposing constraints on the fitting parameters, so to have values that are within experimental ranges. There is some degeneration in the fits, as different sets of parameters provide similarly good fits.ConclusionsThe models provide good fits to experimental data. Mechanistic approaches like this can facilitate the development of mucositis response models to nonstandard schedules/treatment combinations not covered by datasets to which phenomenological models have been fitted. Studying the dynamics of cell populations in multifraction treatments, and finding links with induced toxicity, is the next step of this work.
PB Taylor & Francis
SN 1362-3095
YR 2019
FD 2019-05-15
LK https://hdl.handle.net/10347/38251
UL https://hdl.handle.net/10347/38251
LA eng
NO Parga-Pazos, M., López Pouso, Ó., Fenwick, J. D., & Pardo-Montero, J. (2020). A mathematical model of dynamics of cell populations in squamous epithelium after irradiation. International Journal of Radiation Biology, 1-8. https://doi.org/10.1080/09553002.2020.1787540
NO This is an original manuscript of an article published by Taylor & Francis in International Journal of Radiation Biology on 17 Jul 2020, available at: https://doi.org/10.1080/09553002.2020.1787540
NO This project was funded by Instituto de Salud Carlos III (ISCIII) through research grants PI17/01428 and DTS17/00123 (FEDER co-funding). J.P-M. is supported by ISCIII through a Miguel Servet II grant [CPII17/00028, FEDER co-funding]. O.L.P. is partially supported by FEDER and Xunta de Galicia [GRC2013-014], and by the Spanish Ministry of Science, Innovation and Universities [MTM2017-86459-R]
DS Minerva
RD 22 abr 2026