RT Journal Article
T1 Pre- and postnatal exposure to secondhand tobacco smoke and cardiometabolic risk at 12 years: periods of susceptibility
A1 Mouriño Castro, Nerea
A1 Pérez Ríos, Mónica
A1 Yolton, Kimberly
A1 Lanphear, Bruce P.
A1 Chen, Aimin
A1 Buckley, Jessie P.
A1 Kalkwarf, Heidi J.
A1 Cecil, Kim M.
A1 Braun, Joseph M.
K1 Secondhand tobacco smoke
K1 Cotinine
K1 Adolescents
K1 Cardiometabolic risk factors
AB Background: To identify periods of heightened susceptibility to the association of secondhand tobacco smoke (SHS) exposure with cardiometabolic (CM) risk at age 12 years.Methods: We used data from 212 adolescents from the HOME Study, a prospective pregnancy and birth cohort in Cincinnati, OH. Using multiple informant models, we estimated associations of maternal serum cotinine (mean of concentrations at 16 and 26 weeks of pregnancy) and children's serum cotinine concentrations (mean of concentrations at ages 1, 2, 3, and 4 years) with a CM risk summary score constructed of five risk components measured at age 12 years. We determined if these associations differed for pre- and postnatal exposure periods, and adolescent's sex.Results: We found some evidence that the cotinine-outcome associations differed by exposure period and sex. Postnatal, but not prenatal, cotinine was associated with higher CM risk scores and individual CM risk component values (interaction p-values = 0.04 to 0.35). Each 10-fold increase in postnatal cotinine was associated with 0.57 (95% CI: 0.32, 1.45), 0.09 (95% CI: 0.13, 0.31), 0.14 (-0.08, 0.35), 0.07 (95% CI: 0.34, 0.48), and 0.11 (95% CI: 0.04, 0.27) higher CM risk, HOMA-IR, TG to HDL-C ratio, leptin to adiponectin ratio, and visceral fat area. Postnatal cotinine was associated with higher visceral fat area among females but not males (sex × period × cotinine interaction p-value = 0.01).Conclusions: Serum cotinine concentrations during the postnatal period had greater influence on adolescent's CM risk compared to the prenatal period, and these associations may be sex-specific. This study reinforces the need for ongoing public health interventions to minimize children's exposure to SHS
PB Elsevier
YR 2023
FD 2023
LK http://hdl.handle.net/10347/30615
UL http://hdl.handle.net/10347/30615
LA eng
NO Environmental Research 224 (2023) 115572
NO The HOME Study was funded by National Institutes of Environmental Health Sciences grants P01 ES011261, R01 ES014575 and R01 ES015517. The U.S. National Institutes (National Institute of Environmental Health Sciences), Environmental Protection Agency, Department of Housing and Urban Development, and Flight Attendant Medical Research Institute provided funding for the presented results in the HOME Study
DS Minerva
RD 22 abr 2026