RT Journal Article
T1 Anti-carbamylated protein antibodies as a reproducible independent type of rheumatoid arthritis autoantibodies
A1 Montes, Ariana
A1 Regueiro, Cristina
A1 Pérez Pampín, Eva
A1 Bóveda, María Dolores
A1 Gómez-Reino Carnota, Juan Jesús
A1 González Martínez-Pelayo, Antonio
K1 Rheumatoid Arthritis
K1 Autoantibodies
K1 Antibodies
K1 Enzyme-linked immunoassays
K1 Amino acid analysis
K1 Carbamylation
K1 Fibrinogen
K1 Pathogenesis
AB A large fraction of the patients with rheumatoid arthritis (RA) develop specific autoantibodies, which until recently were only of two types, rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPA). We aimed to replicate important findings about a recently described third type of specific autoantibodies, anti-carbamylated protein (anti-CarP) antibodies, because they have been described based only in the homemade ELISA from a single laboratory. Our study included 520 patients with established RA and 278 healthy controls of Spanish ancestry and it was done with an independently performed ELISA. The prevalence and pattern of environmental, clinical and genetic associations of the anti-CarP antibodies were similar to the previously described. Notably, the presence and titers of anti-CarP correlated with the presence and titers of ACPA, but the anti-CarP antibodies did not share the known genetic and exposure risk factors of the ACPA. In addition, anti-CarP antibodies were independently associated with a higher (10.5%) prevalence of bone erosions. The reproducibility of these characteristics across laboratories and European subpopulations, indicates the wide validity of the results and suggests that determination of anti-CarP antibodies could contribute to explain RA pathogenesis and identify clinically relevant patient subgroups.
PB PLoS ONE
YR 2016
FD 2016-08-18
LK http://hdl.handle.net/10347/15883
UL http://hdl.handle.net/10347/15883
LA eng
NO Montes A, Regueiro C, Perez-Pampin E, Boveda MD, Gomez-Reino JJ, Gonzalez A (2016) Anti-Carbamylated Protein Antibodies as a Reproducible Independent Type of Rheumatoid Arthritis Autoantibodies. PLoS ONE 11(8): e0161141
NO Funding was provided by the Instituto de Salud Carlos III, PI14/01651; and Instituto de SaludCarlos III, RD12/0009/0008. The funders had no role in study design, data collection and analysis, decisionto publish, or preparation of the manuscript.
DS Minerva
RD 22 abr 2026