RT Journal Article
T1 Recent Research in Ocular Cystinosis: Drug Delivery Systems, Cysteamine Detection Methods and Future Perspectives
A1 Castro Balado, Ana
A1 Mondelo García, Cristina
A1 Varela Rey, Iria
A1 Moreda Vizcaíno, Beatriz
A1 Sierra Sánchez, Jesús F.
A1 Rodríguez Ares, María Teresa
A1 Hermelo Vidal, Gonzalo
A1 Zarra Ferro, Irene
A1 González Barcia, Miguel
A1 Yebra-Pimentel Vilar, Eva
A1 Giráldez Fernández, María Jesús
A1 Otero Espinar, Francisco Javier
A1 Fernández Ferreiro, Anxo
K1 Cystinosis
K1 Ophthalmic administration
K1 Cysteamine
K1 Drug delivery systems
K1 Analytical chemistry methods
AB Cystinosis is a rare genetic disorder characterized by the accumulation of cystine crystals in different tissues and organs. Although renal damage prevails during initial stages, the deposition of cystine crystals in the cornea causes severe ocular manifestations. At present, cysteamine is the only topical effective treatment for ocular cystinosis. The lack of investment by the pharmaceutical industry, together with the limited stability of cysteamine, make it available only as two marketed presentations (Cystaran® and Cystadrops®) and as compounding formulations prepared in pharmacy departments. Even so, new drug delivery systems (DDSs) need to be developed, allowing more comfortable dosage schedules that favor patient adherence. In the last decades, different research groups have focused on the development of hydrogels, nanowafers and contact lenses, allowing a sustained cysteamine release. In parallel, different determination methods and strategies to increase the stability of the formulations have also been developed. This comprehensive review aims to compile all the challenges and advances related to new cysteamine DDSs, analytical determination methods, and possible future therapeutic alternatives for treating cystinosis
PB MDPI
YR 2020
FD 2020
LK http://hdl.handle.net/10347/23988
UL http://hdl.handle.net/10347/23988
LA eng
NO Castro-Balado, A.; Mondelo-García, C.; Varela-Rey, I.; Moreda-Vizcaíno, B.; Sierra-Sánchez, J.F.; Rodríguez-Ares, M.T.; Hermelo-Vidal, G.; Zarra-Ferro, I.; González-Barcia, M.; Yebra-Pimentel, E.; Giráldez-Fernández, M.J.; Otero-Espinar, F.J.; Fernández-Ferreiro, A. Recent Research in Ocular Cystinosis: Drug Delivery Systems, Cysteamine Detection Methods and Future Perspectives. Pharmaceutics 2020, 12, 1177
NO This research was funded by Fundación Española de Farmacia Hospitalaria (FEFH 18-19), Fundación Mutua Madrileña (XVI Convocatoria de Ayudas a la Investigación en Salud) and “Asociación La Lucha de Iker”. C.M.-G. and A.F.-F. have funding research grants from Instituto de Salud Carlos III (C.M.-G.-Río Hortega CM18/00090 and A.F.-F.-Juan Rodés JR18/0004)
DS Minerva
RD 28 abr 2026