RT Journal Article
T1 Catalytic Asymmetric Synthesis of Butenolides and Butyrolactones
A1 Mao, Bin
A1 Fañanás-Mastral, Martín
A1 Feringa, Ben L.
AB γ-Butenolides, γ-butyrolactones, and derivatives, especially in enantiomerically pure form, constitute the structural core of numerous natural products which display an impressive range of biological activities which are important for the development of novel physiological and therapeutic agents. Furthermore, optically active γ-butenolides and γ-butyrolactones serve also as a prominent class of chiral building blocks for the synthesis of diverse biological active compounds and complex molecules. Taking into account the varying biological activity profiles and wide-ranging structural diversity of the optically active γ-butenolide or γ-butyrolactone structure, the development of asymmetric synthetic strategies for assembling such challenging scaffolds has attracted major attention from synthetic chemists in the past decade. This review offers an overview of the different enantioselective synthesis of γ-butenolides and γ-butyrolactones which employ catalytic amounts of metal complexes or organocatalysts, with emphasis focused on the mechanistic issues that account for the observed stereocontrol of the representative reactions, as well as practical applications and synthetic potentials.
PB American Chemical Society
SN 0009-2665
YR 2017
FD 2017-06-22
LK http://hdl.handle.net/10347/16979
UL http://hdl.handle.net/10347/16979
LA eng
NO Bin Mao, Martín Fañanás-Mastral, and Ben L. FeringaChemical Reviews 2017 117 (15), 10502-10566DOI: 10.1021/acs.chemrev.7b00151
NO We gratefully acknowledge generous support from The Netherlands Organization for Scientific Research (NWO-CW, Top grant to B.L.F.), the Royal Netherlands Academy of Arts and Sciences (KNAW), the Ministry of Education, Culture and Science (Gravitation Programme 024.001.035), the European Research Council (Advanced Investigator Grant 694345 to B.L.F.), and the Spanish Ministry of Economy and Competitiveness (Ramón y Cajal contract to M.F.-M.). B.M. gratefully thanks the Chinese National Natural Science Foundation (21606200) and the start-up fund from Zhejiang University of Technology for financial support
DS Minerva
RD 22 abr 2026