RT Journal Article
T1 Oxidative Stress Induced by Excess of Adiposity Is Related to a Downregulation of Hepatic SIRT6 Expression in Obese Individuals
A1 Carreira, Marcos C.
A1 González Izquierdo, Andrea
A1 Amil Diz, María
A1 Casanueva Freijo, Felipe
A1 Crujeiras Martínez, Ana Belén
AB Sirt6 is a member of the sirtuin family involved in physiological and pathological processes including aging, cancer, obesity, diabetes, and energy metabolism. This study is aimed at evaluating the relationship between liver SIRT6 gene expression and the oxidative stress network depending on adiposity levels in Zucker rats, an animal model of metabolic syndrome. We observed that liver-specific SIRT6 expression is reduced in an in vivo model of spontaneous obesity and metabolic syndrome. We also observed that SIRT6 expression in the liver is positively associated with SIRT1 and GST-M2 expressions, two proteins involved in antioxidant protection pathways and inversely related to body weight and plasmatic oxidative status. Interestingly, the SIRT6 expression is upregulated after energy restriction-induced weight loss concomitantly with an improvement in oxidative stress markers. These results suggest that SIRT6 may be a potential therapeutic target for the treatment of obesity and associated metabolic disorders, such as liver disease.
PB Hindawi
SN 1942-0900
YR 2018
FD 2018
LK http://hdl.handle.net/10347/22968
UL http://hdl.handle.net/10347/22968
LA eng
NO Carreira, M. C., Izquierdo, A. G., Amil, M., Casanueva, F. F., & Crujeiras, A. B. (2018). Oxidative stress induced by excess of adiposity is related to a downregulation of hepatic SIRT6 expression in obese individuals. Oxidative medicine and cellular longevity, 2018.
NO This study was supported byCentro de Investigacion Biomedica en Red de Fisiopatologiade la Obesidad y Nutricion (CIBERobn) and grants from theInstituto de Salud Carlos III (PI17/01287) cofinanced by theEuropean Regional Development Fund (FEDER). Andrea G.Izquierdo is funded by CIBERobn and Ana B. Crujeiras isfunded by a research contract “Miguel Servet” (CP17/00088) from the Instituto de Salud Carlos III, cofinanced bythe European Regional Development Fund (FEDER)
DS Minerva
RD 22 abr 2026