RT Journal Article
T1 Emerging multidrug-resistant hybrid pathotype shiga toxin-producing escherichia coil O80 and related strains of clonal complex 165, Europe
A1 Cointe, Aurélie
A1 Birgy, André
A1 Mariani-Kurkdjian, Patricia
A1 Ligouri, Sandrine
A1 Courroux, Céline
A1 Blanco Álvarez, Jorge
A1 Delannoy, Sabine
A1 Fach, Patrick
A1 Loukiadis, Estelle
A1 Bidet, Philippe
A1 Bonacorsi, Stéphane
K1 Multidrug-Resistant
K1 Hybrid Pathotype Shiga Toxin
K1 Coli O80
K1 Clonal Complex 165
AB Enterohemorrhagic Escherichia coli serogroup O80, involvedin hemolytic uremic syndrome associated with extraintestinalinfections, has emerged in France. We obtained circularizedsequences of the O80 strain RDEx444, responsible for hemolytic uremic syndrome with bacteremia, and noncircularizedsequences of 35 O80 E. coli isolated from humans and animals in Europe with or without Shiga toxin genes. RDEx444harbored a mosaic plasmid, pR444_A, combining extraintestinal virulence determinants and a multidrug resistance–encoding island. All strains belonged to clonal complex 165,which is distantly related to other major enterohemorrhagic E.coli lineages. All stx-positive strains contained eae-ξ, ehxA,and genes characteristic of pR444_A. Among stx-negativestrains, 1 produced extended-spectrum β-lactamase, 1 harbored the colistin-resistance gene mcr1, and 2 possessedgenes characteristic of enteropathogenic and pyelonephritisE. coli. Because O80–clonal complex 165 strains can integrate intestinal and extraintestinal virulence factors in combination with diverse drug-resistance genes, they constitutedangerous and versatile multidrug-resistant pathogens
PB Centers for Disease Control and Prevention
SN 1080-6040
YR 2018
FD 2018
LK http://hdl.handle.net/10347/22913
UL http://hdl.handle.net/10347/22913
LA eng
NO Cointe, A., Birgy, A., Mariani Kurkdjian, P., Logouri, S., Courroux, C., Blanco, J. et al. (2018). Emerging multidrug-resistant hybrid pathotype shiga toxin–producing escherichia coli O80 and related strains of clonal complex 165, Europe. Emerg. Infect. Dis., vol. 24,12, 2062-2069
NO We thank Roger Stephan and Lothar Beutin for providing thestrains from Switzerland and Germany, respectively.This work was financed by Fonds d’Etudes et de Recherche duCorps Médical, AP-HP. Work in the Laboratorio de Referenciade Escherichia coli was financed by grant no. ED431C-2017-57from Consellería de Cultura, Educación e OrdenaciónUniversitaria (Xunta de Galicia) and the European RegionalDevelopment Fund
DS Minerva
RD 24 abr 2026